Post-ischemic continuous administration of galantamine attenuates cognitive deficits and hippocampal neurons loss after transient global ischemia in gerbils | |
Ji, XH; Li, CY; Lu, Y; Chen, YY; Guo, LH | |
刊名 | NEUROSCIENCE LETTERS |
2007 | |
卷号 | 416期号:1页码:92-95 |
关键词 | brain ischemia galantamine hippocampus gerbil |
通讯作者 | Guo, LH (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol,Lab Genet Engn, 320 Yue Yang Rd, Shanghai, Peoples R China.,mhzhang@sunm.Shcnc.ac.cn |
英文摘要 | The deficits due to global cerebral ischemia show a close correlation with hippocampal CA1 neurons damage. Here we presented that galantamine showed effective protection against ischemic insults. In a transient brain global ischemic model conducted in gerbils, we investigated the alterations of performance in passive avoidance test and the histological changes between sham-operated animals (as controls) and those received post-ischemic continuous administration of saline (vehicle) or galantarnine. Compared to the controls, gerbils received ischemc insults with saline treatment showed significant impairment in performance in passive avoidance test and dramatic loss of cells in hippocampal CA1 region. However, gerbils that received the same insults with galantamine (2 mg/kg/day) treatment performed similarly to the controls. Consistently, most of the cells in hippocampal CA1 region which were vulnerable to ischemic insults, survived after galantamine treatment. Our results suggested that continuous application of galantamine might be effective in treatment of ischemic injury. (c) 2007 Published by Elsevier Ireland Ltd. |
学科主题 | Neurosciences & Neurology |
类目[WOS] | Neurosciences |
关键词[WOS] | VASCULAR DEMENTIA ; ALZHEIMERS-DISEASE ; GALANTHAMINE ; RATS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000246038900018 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/1504] |
专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
推荐引用方式 GB/T 7714 | Ji, XH,Li, CY,Lu, Y,et al. Post-ischemic continuous administration of galantamine attenuates cognitive deficits and hippocampal neurons loss after transient global ischemia in gerbils[J]. NEUROSCIENCE LETTERS,2007,416(1):92-95. |
APA | Ji, XH,Li, CY,Lu, Y,Chen, YY,&Guo, LH.(2007).Post-ischemic continuous administration of galantamine attenuates cognitive deficits and hippocampal neurons loss after transient global ischemia in gerbils.NEUROSCIENCE LETTERS,416(1),92-95. |
MLA | Ji, XH,et al."Post-ischemic continuous administration of galantamine attenuates cognitive deficits and hippocampal neurons loss after transient global ischemia in gerbils".NEUROSCIENCE LETTERS 416.1(2007):92-95. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论