Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification

	Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification
	Shan, SF; Wang, LF; Zhai, JW; Qin, Y; Ouyang, HF; Kong, YY; Liu, J; Wang, Y; Xie, YH
刊名	FEBS LETTERS
	2008
卷号	582 期号:27 页码:3723-3728
关键词	Prox1 Sumoylation HDAC3 Corepressor Transcription
通讯作者	Xie, YH (reprint author), Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Key Lab Med Mol Virol, Shanghai 200032, Peoples R China.,yhxie@sibs.ac.cn
英文摘要	Prospero-related homeobox protein (Prox1) plays essential roles in the development of many tissues and organs. In the present study, we show that Prox1 is modified by the small ubiquitin-like protein SUMO-1 in cultured cells. Mutation analysis identified at least four potential sumoylation sites within the repression domain of Prox1. Our data indicate that sumoylation of Prox1 reduces its interaction with HDAC3 and as a result downregulates its corepressor activity. These findings suggest that sumoylation may serve as a novel mechanism for the regulation of Prox1's corepressor activity.
学科主题	Biochemistry & Molecular Biology; Biophysics; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]	LIVER RECEPTOR HOMOLOG-1 ; ACTIVATION ; GENE
收录类别	SCI
语种	英语
WOS记录号	WOS:000261234800003
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1475]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Shan, SF,Wang, LF,Zhai, JW,et al. Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification[J]. FEBS LETTERS,2008,582(27):3723-3728.
APA	Shan, SF.,Wang, LF.,Zhai, JW.,Qin, Y.,Ouyang, HF.,...&Xie, YH.(2008).Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification.FEBS LETTERS,582(27),3723-3728.
MLA	Shan, SF,et al."Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification".FEBS LETTERS 582.27(2008):3723-3728.