A novel strategy for cancer treatment: Targeting cancer stem cells

	A novel strategy for cancer treatment: Targeting cancer stem cells
	Liu, J; Ma, LN; Wang, YG; Liu, XY; Qian, QJ
刊名	CHINESE SCIENCE BULLETIN
	2008
卷号	53 期号:12 页码:1777-1783
关键词	cancer stem cell targeting oncolytic adenovirus strategy
通讯作者	Qian, QJ (reprint author), Zhejiang Sci Tech Univ, Xin Yuan Inst Med & Biotechnol, Coll Life Sci, Hangzhou 310018, Peoples R China.,qianqj@163.sino-gene.cn
英文摘要	Cancer stem cell/tumor-initiating cell (CSC/TIC) is a subclass of cancer cells possessing parts of properties of normal stem cell. It has a high capacity of proliferation and plays a pivotal role in tumor recurrence and tumor resistance to radiotherapy and chemotherapy. At present, small molecule inhibitors and fusion proteins are widely used in the CSC-targeting strategy. Gene-virotherapy, which uses oncolytic adenovirus as a vector to mediate the expression of therapeutic gene, shows a significant superiority to other regimens of cancer treatment and has a good efficacy in the treatment of solid tumors. Thus, it is a promising choice to apply gene-virotherapy into the CSC-targeting treatment. Based on the molecular mechanism underlying CSC self-renewal, a series of effective strategies for targeting CSC have been established. This review will summarize the recent research progresses on CSC-targeting treatment.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	ACUTE MYELOID-LEUKEMIA ; TUMOR-INITIATING CELLS ; TRANS-RETINOIC ACID ; GENE-THERAPY ; PROSPECTIVE IDENTIFICATION ; ANTITUMORAL EFFICACY ; LENTIVIRAL VECTORS ; PANCREATIC-CANCER ; SIDE POPULATION ; BRAIN-TUMORS
收录类别	SCI
语种	英语
WOS记录号	WOS:000256963000001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1463]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liu, J,Ma, LN,Wang, YG,et al. A novel strategy for cancer treatment: Targeting cancer stem cells[J]. CHINESE SCIENCE BULLETIN,2008,53(12):1777-1783.
APA	Liu, J,Ma, LN,Wang, YG,Liu, XY,&Qian, QJ.(2008).A novel strategy for cancer treatment: Targeting cancer stem cells.CHINESE SCIENCE BULLETIN,53(12),1777-1783.
MLA	Liu, J,et al."A novel strategy for cancer treatment: Targeting cancer stem cells".CHINESE SCIENCE BULLETIN 53.12(2008):1777-1783.