An Identification of Stem Cell-Resembling Gene Expression Profiles in High-Grade Astrocytomas

	An Identification of Stem Cell-Resembling Gene Expression Profiles in High-Grade Astrocytomas
	Yang, Y; Qiu, YM; Ren, WW; Gong, JL; Chen, FX
刊名	MOLECULAR CARCINOGENESIS
	2008
卷号	47 期号:11 页码:893-903
关键词	microarray neural stem cells gliomas gene expression profile cancer stem cells
通讯作者	Chen, FX (reprint author), Shanghai Univ, Sch Life Sci, 99 ShangDa Rd, Shanghai 200444, Peoples R China.,
英文摘要	High-grade astrocytomas are among the most intractable types of cancers and are often fatal. Previous studies have suggested that high-grade astrocytomas may adopt the self-renewal and migration properties of neural stem cells (NSCs) to proliferate and spread by expressing the stem cell-specific genes. However, despite a few common molecules being documented, the molecular basis underlying these similarities remains largely unknown. To have a better understanding of the stem cell characteristics of high-grade astrocytomas, we performed the study to identify the stem cell-resembling gene expression profile in high-grade astrocytomas. cDNA microarray analysis was used to detect the differentially expressed genes of isolated human high-grade astrocytomas versus their peritumoral tissue counterparts, and the identification of stem cell-resembling genes was approached by comparing the high-grade astrocytomas-specific gene expression profile with that of NSCs identified by our previous study and other groups. We identified more than 200 high-grade astrocytomas-specific genes in this study, and near 10% genes or gene families of them exhibited similar up or down expression patterns as in NSCs. Further analysis indicated that these genes were actively involved in cell proliferation, adhesion, migration, and metastasis. This study revealed a list of stem cell-specific genes. in high-grade astrocytomas, which was likely to have critical roles in determining the "stem" characteristics of high-grade astrocytomas. (C) 2008 Wiley-Liss, Inc.
学科主题	Biochemistry & Molecular Biology; Oncology
类目[WOS]	Biochemistry & Molecular Biology ; Oncology
关键词[WOS]	MICROARRAY ANALYSIS ; BRAIN-TUMOR ; CANCER ; DIFFERENTIATION ; PROGRESSION ; ROLES ; MECHANISMS ; CLUSTERIN ; ISOMERASE ; PATHWAYS
收录类别	SCI
语种	英语
WOS记录号	WOS:000260808100006
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1454]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yang, Y,Qiu, YM,Ren, WW,et al. An Identification of Stem Cell-Resembling Gene Expression Profiles in High-Grade Astrocytomas[J]. MOLECULAR CARCINOGENESIS,2008,47(11):893-903.
APA	Yang, Y,Qiu, YM,Ren, WW,Gong, JL,&Chen, FX.(2008).An Identification of Stem Cell-Resembling Gene Expression Profiles in High-Grade Astrocytomas.MOLECULAR CARCINOGENESIS,47(11),893-903.
MLA	Yang, Y,et al."An Identification of Stem Cell-Resembling Gene Expression Profiles in High-Grade Astrocytomas".MOLECULAR CARCINOGENESIS 47.11(2008):893-903.