Essential role of sphingosine-1-phosphate receptor 1-bearing CD8(+)CD44(+)CCR7(+) T cells in acute skin allograft rejection (Retracted article. See vol. 11, pg. 1343, 2011)

	Essential role of sphingosine-1-phosphate receptor 1-bearing CD8(+)CD44(+)CCR7(+) T cells in acute skin allograft rejection (Retracted article. See vol. 11, pg. 1343, 2011)
	Yuling, H; Ruijing, X; Xiang, J; Luokun, X; Wenjun, Y; Feng, C; Baojun, H; Hui, Y; Guang, Y; Chunlei, Y
刊名	AMERICAN JOURNAL OF TRANSPLANTATION
	2008
卷号	8 期号:7 页码:1401-1412
关键词	acute allograft rejection chemokine receptor cytotoxicity memory T cells siRNA
通讯作者	Feili, G (reprint author), Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan 430074, Peoples R China.,flgong@tjmu.edu.cn ; jinquan_tan@whu.edu.cn
英文摘要	A subset of naturally formed sphingosine-1-phosphate receptor 1 (S1P1)-bearing CD8(+)CD44(+)CCR7(+) memory T cells has been identified in transplant recipient BALB/c (H-2(d)) mice. The frequency of this subset of memory T cells is significantly increased in the spleen, lymph nodes and skin grafts in the recipient BALB/c mice during acute skin allograft rejections. The immune-reconstitution with CD8(+)CD44(+)CCR7(+)S1P1(+) memory T cells facilitates acute skin allograft rejection in SCID mice. Being Th1-polarized and cytotoxic, CD8(+)CD44(+)CCR7(+)S1P1(+) memory T cells proliferate and differentiate immediately into effectors upon encountering allo-antigens. A siRNA against S1P1 inhibits CD8(+)CD44(+)CCR7(+)S1P1(+) memory T cell-mediated acute skin allograft rejection in SCID mice by means of knocking-down S1P1-expression. CCL21 mutant (CCL21-Delta CT) has been used to compete with wild-type CCL21 in the course of binding to CCR7. Combined administration of siRNA S1P1 and CCL21-Delta CT significantly prolongs the survival of skin allograft in the recipient BALB/c mice by means of inhibiting accumulation of CD8(+)CD44(+)CCR7(+)S1P1(+) memory T cells in the spleen and the skin grafts. Our data provide direct evidence that S1P1 and CCR7 are involved in the proliferation and trafficking of CD8(+)CD44(+)CCR7(+)S1P1(+) memory T cells. S1P1 may serve as a functional marker for CD8(+)CD44(+)CCR7(+) memory T cells. Targeting CD8(+)CD44(+)CCR7(+)S1P1(+) T cells may be a useful strategy to prolong the survival of allograft transplant.
学科主题	Surgery; Transplantation
类目[WOS]	Surgery ; Transplantation
关键词[WOS]	HETEROLOGOUS ANTIVIRAL IMMUNITY ; DENDRITIC CELLS ; TRANSPLANTATION TOLERANCE ; SPHINGOSINE 1-PHOSPHATE ; LYMPHOCYTE EGRESS ; BLOOD LYMPHOCYTES ; CUTTING EDGE ; MEMORY CELLS ; EXPRESSION ; DIFFERENTIATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000257549800011
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1403]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yuling, H,Ruijing, X,Xiang, J,et al. Essential role of sphingosine-1-phosphate receptor 1-bearing CD8(+)CD44(+)CCR7(+) T cells in acute skin allograft rejection (Retracted article. See vol. 11, pg. 1343, 2011)[J]. AMERICAN JOURNAL OF TRANSPLANTATION,2008,8(7):1401-1412.
APA	Yuling, H.,Ruijing, X.,Xiang, J.,Luokun, X.,Wenjun, Y.,...&Jinquan, T.(2008).Essential role of sphingosine-1-phosphate receptor 1-bearing CD8(+)CD44(+)CCR7(+) T cells in acute skin allograft rejection (Retracted article. See vol. 11, pg. 1343, 2011).AMERICAN JOURNAL OF TRANSPLANTATION,8(7),1401-1412.
MLA	Yuling, H,et al."Essential role of sphingosine-1-phosphate receptor 1-bearing CD8(+)CD44(+)CCR7(+) T cells in acute skin allograft rejection (Retracted article. See vol. 11, pg. 1343, 2011)".AMERICAN JOURNAL OF TRANSPLANTATION 8.7(2008):1401-1412.