Activin/nodal signaling modulates XPAPC expression during Xenopus gastrulation

	Activin/nodal signaling modulates XPAPC expression during Xenopus gastrulation
	Lou, X; Li, SW; Wang, JH; Ding, XY
刊名	DEVELOPMENTAL DYNAMICS
	2008
卷号	237 期号:3 页码:683-691
关键词	gastrulation nodal signaling XPAPC Xenopus
通讯作者	Ding, XY (reprint author), Room 1102,Cell Bldg,320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xyding@sunm.shcne.ae.en
英文摘要	Gastrulation is the first obligatory morphogenesis during vertebrate development, by which the body plan is established. Nodal signaling is a key player in many developmental processes, including gastrulation. XPAPC has been found to exert its biological function through modifying the adhesion property of cells and interacting with other several important molecules in embryos. In this report, we show that nodal signaling is necessary and sufficient for XPAPC expression during Xenopus gastrulation. Furthermore, we isolated 4.8 kb upstream DNA sequence of Xenopus XPAPC, and proved that this 4.8-kb genomic contig is sufficient to recapitulate the expression pattern of XPAPC from gastrula to tail bud stage. Transgene and ChIP assays indicate that Activin/nodal signaling participates in regulation of XPAPC expression through a Smad binding element within the XPAPC promoter. Concomitant investigation suggests that the canonical Wnt pathway-activated XPAPC expression requires nodal signaling.
学科主题	Anatomy & Morphology; Developmental Biology
类目[WOS]	Anatomy & Morphology ; Developmental Biology
关键词[WOS]	CONVERGENT EXTENSION MOVEMENTS ; PARAXIAL PROTOCADHERIN ; VERTEBRATE DEVELOPMENT ; MOLECULAR-MECHANISM ; WNT/BETA-CATENIN ; CELL MOVEMENTS ; IN-VIVO ; MESODERM ; EMBRYOS ; SPECIFICATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000254232200014
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1361]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Lou, X,Li, SW,Wang, JH,et al. Activin/nodal signaling modulates XPAPC expression during Xenopus gastrulation[J]. DEVELOPMENTAL DYNAMICS,2008,237(3):683-691.
APA	Lou, X,Li, SW,Wang, JH,&Ding, XY.(2008).Activin/nodal signaling modulates XPAPC expression during Xenopus gastrulation.DEVELOPMENTAL DYNAMICS,237(3),683-691.
MLA	Lou, X,et al."Activin/nodal signaling modulates XPAPC expression during Xenopus gastrulation".DEVELOPMENTAL DYNAMICS 237.3(2008):683-691.