Activin/nodal signaling modulates XPAPC expression during Xenopus gastrulation | |
Lou, X; Li, SW; Wang, JH; Ding, XY | |
刊名 | DEVELOPMENTAL DYNAMICS
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2008 | |
卷号 | 237期号:3页码:683-691 |
关键词 | gastrulation nodal signaling XPAPC Xenopus |
通讯作者 | Ding, XY (reprint author), Room 1102,Cell Bldg,320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xyding@sunm.shcne.ae.en |
英文摘要 | Gastrulation is the first obligatory morphogenesis during vertebrate development, by which the body plan is established. Nodal signaling is a key player in many developmental processes, including gastrulation. XPAPC has been found to exert its biological function through modifying the adhesion property of cells and interacting with other several important molecules in embryos. In this report, we show that nodal signaling is necessary and sufficient for XPAPC expression during Xenopus gastrulation. Furthermore, we isolated 4.8 kb upstream DNA sequence of Xenopus XPAPC, and proved that this 4.8-kb genomic contig is sufficient to recapitulate the expression pattern of XPAPC from gastrula to tail bud stage. Transgene and ChIP assays indicate that Activin/nodal signaling participates in regulation of XPAPC expression through a Smad binding element within the XPAPC promoter. Concomitant investigation suggests that the canonical Wnt pathway-activated XPAPC expression requires nodal signaling. |
学科主题 | Anatomy & Morphology; Developmental Biology |
类目[WOS] | Anatomy & Morphology ; Developmental Biology |
关键词[WOS] | CONVERGENT EXTENSION MOVEMENTS ; PARAXIAL PROTOCADHERIN ; VERTEBRATE DEVELOPMENT ; MOLECULAR-MECHANISM ; WNT/BETA-CATENIN ; CELL MOVEMENTS ; IN-VIVO ; MESODERM ; EMBRYOS ; SPECIFICATION |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000254232200014 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/1361] ![]() |
专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
推荐引用方式 GB/T 7714 | Lou, X,Li, SW,Wang, JH,et al. Activin/nodal signaling modulates XPAPC expression during Xenopus gastrulation[J]. DEVELOPMENTAL DYNAMICS,2008,237(3):683-691. |
APA | Lou, X,Li, SW,Wang, JH,&Ding, XY.(2008).Activin/nodal signaling modulates XPAPC expression during Xenopus gastrulation.DEVELOPMENTAL DYNAMICS,237(3),683-691. |
MLA | Lou, X,et al."Activin/nodal signaling modulates XPAPC expression during Xenopus gastrulation".DEVELOPMENTAL DYNAMICS 237.3(2008):683-691. |
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