Glucocorticoid-induced apoptosis requires FOXO3A activity

	Glucocorticoid-induced apoptosis requires FOXO3A activity
	Ma, JX; Xie, YH; Shi, Y; Qin, WM; Zhao, BT; Jin, YX
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2008
卷号	377 期号:3 页码:894-898
关键词	Glucocorticoids Forkhead transcription factor FOXO3A Apoptosis Phosphorylation Dexamethasone induced cell death
通讯作者	Xie, YH (reprint author), Fudan Univ, Huashan Hosp Affiliated, Dept Hematol, Shanghai 200040, Peoples R China.,xyh@medmail.com.cn ; yxjin@sibs.ac.cn
英文摘要	Dexamethasone (DEX) induces apoptosis in lymphocytes, while protecting some cancer cells from apoptosis, by a poorly understood mechanism. In this study, we examined the potential role of the forkhead transcription factor (FOXO3A) in DEX-induced apoptosis. Unphosphorylated FOXO3A. the active form of FOXO3A, can translocate into nucleus and induce apoptosis. In lymphocytes, FOXO3A is upregulated by DEX treatment, while phospho-FOXO3A was downregulated. In several different types of cancer cells, we found that sensitivity to DEX correlated negatively to expression of phospho-FOXO3A. We Conclude that DEX might maintain FOXO3A in its unphosphorylated, active form. Knockdown of FOXO3A expression using a small interfering RNA (siRNA) significantly reduces apoptosis in lymphocytes. This Study Suggests that FOXO3A has a pivotal role in DEX-induced apoptosis. Increased phospho-FOXO3A levels in cancer cells may explain. in part, their resistance to apoptosis. Therefore, FOXO3A may be a potential target for cancer therapy. (C) 2008 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	FORKHEAD TRANSCRIPTION FACTORS ; CELL-SURVIVAL
收录类别	SCI
语种	英语
WOS记录号	WOS:000261458900030
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1352]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Ma, JX,Xie, YH,Shi, Y,et al. Glucocorticoid-induced apoptosis requires FOXO3A activity[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,377(3):894-898.
APA	Ma, JX,Xie, YH,Shi, Y,Qin, WM,Zhao, BT,&Jin, YX.(2008).Glucocorticoid-induced apoptosis requires FOXO3A activity.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,377(3),894-898.
MLA	Ma, JX,et al."Glucocorticoid-induced apoptosis requires FOXO3A activity".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 377.3(2008):894-898.