Hypoalgesia in mice lacking GABA transporter subtype

	Hypoalgesia in mice lacking GABA transporter subtype
	Xu, YF; Cai, YQ; Cai, GQ; Jiang, J; Sheng, ZJ; Wang, ZG; Fei, J
刊名	JOURNAL OF NEUROSCIENCE RESEARCH
	2008
卷号	86 期号:2 页码:465-470
关键词	GABA transporter tail-immersion test hot-plate test abdominal constriction test formalin test
通讯作者	Fei, J (reprint author), Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China.,jfeil24@126.com
英文摘要	gamma-Aminobutyric acid (GABA) transporters play a key role in the regulation of GABA neurotransmission. We reported previously that overexpression of the GABA transporter subtype 1 (GAT1), the major form of the GABA transporter in the CNS, led to hyperalgesia in mice. In the present study, nociceptive responses of GAT1-knockout mice (GAT1(-/-)) were compared with those of heterozygous (GAT(+/-)) and wild-type (GAT(+/+)) mice by four conventional pain models (tail-immersion test, hot-plate test, acetic acid-induced abdominal constriction test, and formalin test). In addition, the analgesic effects of two GAT1-selective inhibitors, NO-711 and tiagabine, were examined in all three genotypes using the same four models. Our data demonstrated that GAT1 deficiency because of genetic knockout or acute blockade by selective inhibitors leads to hypoalgesia in mice. These results confirmed the crucial role of GAT1 in the regulation of nociceptive threshold and suggested that GAT1 inhibitors have the potential for clinical use in pain therapy. (C) 2007 Wiley-Liss, Inc.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	FACIAL CARRAGEENAN INJECTIONS ; BRAIN-STEM ; MOUSE ; HYPERALGESIA ; NOCICEPTION ; GABAPENTIN ; ACTIVATION ; EXPRESSION ; ANALGESIA ; TIAGABINE
收录类别	SCI
语种	英语
WOS记录号	WOS:000253005300025
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1346]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Xu, YF,Cai, YQ,Cai, GQ,et al. Hypoalgesia in mice lacking GABA transporter subtype[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2008,86(2):465-470.
APA	Xu, YF.,Cai, YQ.,Cai, GQ.,Jiang, J.,Sheng, ZJ.,...&Fei, J.(2008).Hypoalgesia in mice lacking GABA transporter subtype.JOURNAL OF NEUROSCIENCE RESEARCH,86(2),465-470.
MLA	Xu, YF,et al."Hypoalgesia in mice lacking GABA transporter subtype".JOURNAL OF NEUROSCIENCE RESEARCH 86.2(2008):465-470.