The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinson's Disease Related Protein

	The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinson's Disease Related Protein
	Fu, QS; Song, AX; Li, SX; Hu, HY
刊名	PROTEIN AND PEPTIDE LETTERS
	2009
卷号	16 期号:12 页码:1442-1446
关键词	LRRK2 ROC domain small GTPase GTP binding Parkinson's disease
通讯作者	Hu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,hyhu@sibs.ac.cn
英文摘要	Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinson's disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinson's disease-associated mutants do not appear to have reduced GTP hydrolysis activities.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	KINASE-ACTIVITY ; P21(H-RAS) PROTEIN ; NEURONAL TOXICITY ; LIGAND-BINDING ; MUTATIONS ; GENE ; MECHANISM ; HYDROLYSIS ; INSIGHTS
收录类别	SCI
语种	英语
WOS记录号	WOS:000271620200005
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1271]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Fu, QS,Song, AX,Li, SX,et al. The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinson's Disease Related Protein[J]. PROTEIN AND PEPTIDE LETTERS,2009,16(12):1442-1446.
APA	Fu, QS,Song, AX,Li, SX,&Hu, HY.(2009).The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinson's Disease Related Protein.PROTEIN AND PEPTIDE LETTERS,16(12),1442-1446.
MLA	Fu, QS,et al."The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinson's Disease Related Protein".PROTEIN AND PEPTIDE LETTERS 16.12(2009):1442-1446.