MicroRNA expression profiling during neural differentiation of mouse embryonic carcinoma P19 cells

	MicroRNA expression profiling during neural differentiation of mouse embryonic carcinoma P19 cells
	Huang, B; Li, W; Zhao, B; Xia, CA; Liang, RQ; Ruan, KC; Jing, NH; Jin, YX
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2009
卷号	41 期号:3 页码:231-236
关键词	microRNA embryonic carcinoma P19 cell neural stem cells neural differentiation
通讯作者	Jin, YX (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,yxjin@sibs.ac.cn
英文摘要	MicroRNAs (or miRNAs) are small non-coding RNAs (21-25 nucleotides) that are involved in a wide range of activities related to the development and differentiation of cells. Comparison of the miRNA expression profiles of mouse P19 embryonic carcinoma cells with those of differentiated neural stem cells showed that the expression level of 65 miRNAs changed (2-fold) after differentiation. MiR-124a was dramatically up-regulated (more than 20-fold) while miRNAs of the miR-302 family and those in the miR-290-295 cluster were strongly down-regulated. Further analysis revealed that some important factors such as Oct4 and Sox2 appeared to be involved in the regulation of these miRNAs. These results may contribute to a better understanding of miRNA-regulated neural differentiation in early mouse embryos.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	STEM-CELLS ; NEURONAL DIFFERENTIATION ; IDENTIFICATION ; NETWORK ; TARGETS
收录类别	SCI
语种	英语
WOS记录号	WOS:000263943400007
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1162]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Huang, B,Li, W,Zhao, B,et al. MicroRNA expression profiling during neural differentiation of mouse embryonic carcinoma P19 cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2009,41(3):231-236.
APA	Huang, B.,Li, W.,Zhao, B.,Xia, CA.,Liang, RQ.,...&Jin, YX.(2009).MicroRNA expression profiling during neural differentiation of mouse embryonic carcinoma P19 cells.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,41(3),231-236.
MLA	Huang, B,et al."MicroRNA expression profiling during neural differentiation of mouse embryonic carcinoma P19 cells".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 41.3(2009):231-236.