Acyl-coenzyme A: cholesterol acyltransferases

	Acyl-coenzyme A: cholesterol acyltransferases
	Chang, TY; Li, BL; Chang, CCY; Urano, Y
刊名	AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
	2009
卷号	297 期号:1 页码:E1-E9
关键词	acyl-coenzyme A: cholesterol acyltransferase inhibitors atherosclerosis Alzheimer's disease
通讯作者	Chang, TY (reprint author), Dartmouth Med Sch, Dept Biochem, 1 Rope Ferry Rd, Hanover, NH 03755 USA.,Ta.Yuan.Chang@Dartmouth.edu
英文摘要	Chang TY, Li BL, Chang CC, Urano Y. Acyl-coenzyme A: cholesterol acyltransferases. Am J Physiol Endocrinol Metab 297: E1-E9, 2009. First published January 13, 2009; doi:10.1152/ajpendo.90926.2008.-The enzymes acylcoenzyme A (CoA): cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues. This chapter summarizes the current knowledge on ACAT-related research in two areas: 1) ACAT genes and proteins and 2) ACAT enzymes as drug targets for atherosclerosis and for Alzheimer's disease.
学科主题	Endocrinology & Metabolism; Physiology
类目[WOS]	Endocrinology & Metabolism ; Physiology
关键词[WOS]	MONOCYTE-DERIVED MACROPHAGES ; HAMSTER OVARY CELLS ; E-DEFICIENT MICE ; ISOFORM-SPECIFIC INHIBITOR ; 2 DIFFERENT CHROMOSOMES ; ACAT INHIBITOR ; IN-VITRO ; ATHEROSCLEROTIC LESIONS ; ENDOPLASMIC-RETICULUM ; ALZHEIMERS-DISEASE
收录类别	SCI
语种	英语
WOS记录号	WOS:000268250900001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1119]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chang, TY,Li, BL,Chang, CCY,et al. Acyl-coenzyme A: cholesterol acyltransferases[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,2009,297(1):E1-E9.
APA	Chang, TY,Li, BL,Chang, CCY,&Urano, Y.(2009).Acyl-coenzyme A: cholesterol acyltransferases.AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,297(1),E1-E9.
MLA	Chang, TY,et al."Acyl-coenzyme A: cholesterol acyltransferases".AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 297.1(2009):E1-E9.