Safflower extracts functionally regulate monoamine transporters | |
Zhao, G; Zheng, XW; Gai, Y; Chu, WJ; Qin, GW; Guo, LH | |
刊名 | JOURNAL OF ETHNOPHARMACOLOGY |
2009 | |
卷号 | 124期号:1页码:116-124 |
关键词 | Safflower Dopamine Norepinephrine Serotonin Reuptake modulator Transporter |
通讯作者 | Guo, LH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,lhguo@sibs.ac.cn |
英文摘要 | Safflower (HH), the dry flower of Carthamus tinctorius L, has long been used to empirically treat neuropsychological disorders such as stroke and major depression in traditional Chinese medicine, and recently been proven effective for regulating levels of dopamine and serotonin in new-born rat brain. The present study assessed whether HH would be bioactive for functionally regulating monoamine transporters using in vitro drug-screening cell lines. Our current results showed that all solvent-extracted HH fractions, in different degrees, markedly increased both dopamine uptake by Chinese hamster ovary (CHO) cells stably expressing dopamine transporter (DAT) and norepinephrine uptake by CHO cells expressing norepinephrine transporter (NET), and also showed that chloroform (HC), ethyl acetate (HE), and n-butyl alcohol extract strikingly depressed serotonin uptake by CHO cells expressing serotonin transporter (SERT); wherein, the potencies of ethanol extract, HC, HE, and aqueous extract to up-regulate dopamine/norepinephrine uptake and potency of HE to inhibit serotonin uptake were relatively stronger. Further investigation revealed that the enhancement of dopamine/norepinephrine uptake by HC and HE was dependent of DAT/NET activity, and the HE-induced inhibition of serotonin uptake was typical of competition. Thus, HH extracts are novel monoamine transporter modulators functioning as DAT/NET activators and/or SERT inhibitors, and would likely improve neuropsychological disorders through regulating monoamine-transporter activity. (C) 2009 Elsevier Ireland Ltd. All rights reserved. |
学科主题 | Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine |
类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
关键词[WOS] | DOPAMINE TRANSPORTER ; CARTHAMUS-TINCTORIUS ; HYDROXYSAFFLOR-YELLOW ; SEROTONIN DERIVATIVES ; LINOLENIC ACID ; RAT-BRAIN ; IN-VITRO ; MICE ; DYSFUNCTION ; BEHAVIOR |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000268201200014 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/1118] |
专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
推荐引用方式 GB/T 7714 | Zhao, G,Zheng, XW,Gai, Y,et al. Safflower extracts functionally regulate monoamine transporters[J]. JOURNAL OF ETHNOPHARMACOLOGY,2009,124(1):116-124. |
APA | Zhao, G,Zheng, XW,Gai, Y,Chu, WJ,Qin, GW,&Guo, LH.(2009).Safflower extracts functionally regulate monoamine transporters.JOURNAL OF ETHNOPHARMACOLOGY,124(1),116-124. |
MLA | Zhao, G,et al."Safflower extracts functionally regulate monoamine transporters".JOURNAL OF ETHNOPHARMACOLOGY 124.1(2009):116-124. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论