MAPK signaling in inflammation-associated cancer development | |
Huang, PY; Han, JH; Hui, LJ | |
刊名 | PROTEIN & CELL |
2010 | |
卷号 | 1期号:3页码:218-226 |
通讯作者 | Han, JH (reprint author), Xiamen Univ, Sch Life Sci, Minist Educ Cell Biol & Tumor Cell Engn, Key Lab, Xiamen 361005, Peoples R China.,jhan@xmu.edu.cn ; ljhui@sibs.ac.cn |
英文摘要 | Mitogen-activated protein (MAP) kinases comprise a family of protein-serine/threonine kinases, which are highly conserved in protein structures from unicellular eukaryotic organisms to multicellular organisms, including mammals. These kinases, including ERKs, JNKs and p38s, are regulated by a phosphorelay cascade, with a prototype of three protein kinases that sequentially phosphorylate one another. MAPKs transduce extracellular signals into a variety of cellular processes, such as cell proliferation, survival, death, and differentiation. Consistent with their essential cellular functions, MAPKs have been shown to play critical roles in embryonic development, adult tissue homeostasis and various pathologies. In this review, we discuss recent findings that reveal the profound impact of these pathways on chronic inflammation and, particularly, inflammation-associated cancer development. |
学科主题 | Cell Biology |
类目[WOS] | Cell Biology |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000208510600004 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/980] |
专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
推荐引用方式 GB/T 7714 | Huang, PY,Han, JH,Hui, LJ. MAPK signaling in inflammation-associated cancer development[J]. PROTEIN & CELL,2010,1(3):218-226. |
APA | Huang, PY,Han, JH,&Hui, LJ.(2010).MAPK signaling in inflammation-associated cancer development.PROTEIN & CELL,1(3),218-226. |
MLA | Huang, PY,et al."MAPK signaling in inflammation-associated cancer development".PROTEIN & CELL 1.3(2010):218-226. |
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