Involvement of CENP-F in histone methylation

	Involvement of CENP-F in histone methylation
	Du, J; Li, Y; Zhu, XL
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2010
卷号	42 期号:3 页码:173-176
关键词	CENP-F mitosin histone methylation HP1
通讯作者	Zhu, XL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,xlzhu@sibs.ac.cn
英文摘要	CENP-F (also named mitosin) is a multifunctional protein of 350 kDa. In interphase, it is a nuclear protein, whereas in M phase it localizes to the kinetochore, the major microtubule-binding structure on chromosomes essential for chromosome segregation. CENP-F is also critical for myocyte differentiation through the interaction with Rb. It binds to ATF4 and negatively regulates the transcriptional activity of ATF4. It is also important for mitotic progression. Here we show that depletion of CENP-F by RNAi markedly downregulated the methylation of histone H3 at K4 and K9. Consistently, association of HP1 alpha with mitotic chromosomes was largely decreased. These results uncover a novel role of CENP-F in regulation of epigenetic modification on histone H3.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	MITOSIN/CENP-F ; CYTOPLASMIC DYNEIN ; LYSINE METHYLATION ; CELL-CYCLE ; PROTEIN ; LOCALIZATION ; HP1 ; PHOSPHORYLATION ; DIFFERENTIATION ; KINETOCHORES
收录类别	SCI
语种	英语
WOS记录号	WOS:000274780600001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/975]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Du, J,Li, Y,Zhu, XL. Involvement of CENP-F in histone methylation[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2010,42(3):173-176.
APA	Du, J,Li, Y,&Zhu, XL.(2010).Involvement of CENP-F in histone methylation.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,42(3),173-176.
MLA	Du, J,et al."Involvement of CENP-F in histone methylation".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 42.3(2010):173-176.