Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers

	Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers
	Li, CG; Fang, R; Sun, YH; Han, XK; Li, F; Gao, B; Iafrate, AJ; Liu, XY; Pao, W; Chen, HQ
刊名	PLOS ONE
	2011
卷号	6 期号:11 页码:e28204-e28204
通讯作者	Li, CG (reprint author), Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China.,william.pao@vanderbilt.edu ; hqchen1@yahoo.com ; hbji@sibs.ac.cn
英文摘要	Purpose: We previously showed that 90% (47 of 52; 95% CI, 0.79 to 0.96) of lung adenocarcinomas from East Asian never-smokers harbored well-known oncogenic mutations in just four genes: EGFR, HER2, ALK, and KRAS. Here, we sought to extend these findings to more samples and identify driver alterations in tumors negative for these mutations. Experimental Design: We have collected and analyzed 202 resected lung adenocarcinomas from never smokers seen at Fudan University Shanghai Cancer Center. Since mutations were mutually exclusive in the first 52 examined, we determined the status of EGFR, KRAS, HER2, ALK, and BRAF in stepwise fashion as previously described. Samples negative for mutations in these 5 genes were subsequently examined for known ROS1 fusions by RT-PCR and direct sequencing. Results: 152 tumors (75.3%) harbored EGFR mutations, 12 (6%) had HER2 mutations, 10 (5%) had ALK fusions all involving EML4 as the 59 partner, 4 (2%) had KRAS mutations, and 2 (1%) harbored ROS1 fusions. No BRAF mutation were detected. Conclusion: The vast majority (176 of 202; 87.1%, 95% CI: 0.82 to 0.91) of lung adenocarcinomas from never smokers harbor mutant kinases sensitive to available TKIs. Interestingly, patients with EGFR mutant patients tend to be older than those without EGFR mutations (58.3 Vs 54.3, P = 0.016) and patient without any known oncogenic driver tend to be diagnosed at a younger age (52.3 Vs 57.9, P = 0.013). Collectively, these data indicate that the majority of never smokers with lung adenocarcinoma could benefit from treatment with a specific tyrosine kinase inhibitor.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	CANCER STATISTICS ; EGFR ; DIAGNOSIS ; SURVIVAL ; KINASES ; FUSION ; TRIAL
收录类别	SCI
语种	英语
WOS记录号	WOS:000298168100050
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/865]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Li, CG,Fang, R,Sun, YH,et al. Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers[J]. PLOS ONE,2011,6(11):e28204-e28204.
APA	Li, CG.,Fang, R.,Sun, YH.,Han, XK.,Li, F.,...&Ji, HB.(2011).Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers.PLOS ONE,6(11),e28204-e28204.
MLA	Li, CG,et al."Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers".PLOS ONE 6.11(2011):e28204-e28204.