ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells

	ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells
	Zhang, Y; Yu, GY; Wang, DM; Hu, Y; Lei, WW
刊名	TOXICON
	2011
卷号	57 期号:6 页码:932-937
关键词	HDAC inhibitor TSA Apoptosis ERK1/2 Non-cancer cells Cancer cells
通讯作者	Lei, WW (reprint author), Kunming Univ Sci & Technol, Lab Mol Genet Aging & Tumor, Fac Life Sci & Technol, 296 Bailongsi Rd, Kunming 650224, Peoples R China.,leiweiwei@kmust.edu.cn
英文摘要	Histone deacetylase (HDAC) inhibitors are candidates of anti-cancer drugs as they can effectively kill cancer cells while have little or no toxicity to non-cancer cells, but the molecular mechanism underlying this process remains unclear. We previously reported that HDAC inhibitors could protect normal mouse hepatocytes from apoptosis induced by transforming growth factor-beta 1 (TGF-beta 1) with the requirement of extracellular signal-regulated kinase 1/2 (ERK1/2). In this study, we investigate the roles of trichostatin A (TSA), a typical HDAC inhibitor, on three non-cancer cell lines AML-12, MDCK and 3T3-L1, and four cancer cell lines Hep-3B, HeLa, A549 and MCF-7. TSA is a fermentation product of Streptomyces originally used as an antifungal agent. Our results showed that TSA blocked not only the TGF-beta 1-induced apoptosis but also serum starvation-induced apoptosis in all the non-cancer cells, whereas it could induce strong apoptosis in all the cancer cells. Further investigation revealed that TSA can induce the activation of ERK1/2 in the three non-cancer cells but not in the cancer cells. In summary, these findings indicated that TSA protect non-cancer cells from apoptosis via activating ERK1/2, providing a useful insight into the better application of HDAC inhibitors in cancer therapy. (C) 2011 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy; Toxicology
类目[WOS]	Pharmacology & Pharmacy ; Toxicology
关键词[WOS]	HISTONE-DEACETYLASE INHIBITORS ; HEPATOMA-CELLS ; APOPTOSIS ; GROWTH ; OSTEOSARCOMA ; SPECIFICITY ; TRANSITION ; MECHANISMS ; SURVIVAL ; THERAPY
收录类别	SCI
语种	英语
WOS记录号	WOS:000290696900014
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/827]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, Y,Yu, GY,Wang, DM,et al. ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells[J]. TOXICON,2011,57(6):932-937.
APA	Zhang, Y,Yu, GY,Wang, DM,Hu, Y,&Lei, WW.(2011).ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells.TOXICON,57(6),932-937.
MLA	Zhang, Y,et al."ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells".TOXICON 57.6(2011):932-937.