Mitochondrial Ubiquitin Ligase MARCH5 Promotes TLR7 Signaling by Attenuating TANK Action

	Mitochondrial Ubiquitin Ligase MARCH5 Promotes TLR7 Signaling by Attenuating TANK Action
	Shi, HX; Liu, X; Wang, Q; Tang, PP; Liu, XY; Shan, YF; Wang, C
刊名	PLOS PATHOGENS
	2011
卷号	7 期号:5 页码:e1002057-e1002057
通讯作者	Shi, HX (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Mol Cell Biol Lab, Shanghai, Peoples R China.,cwang01@sibs.ac.cn
英文摘要	The signaling of Toll-like receptors (TLRs) is the host's first line of defense against microbial invasion. The mitochondrion is emerging as a critical platform for antiviral signal transduction. The regulatory role of mitochondria for TLR signaling remains to be explored. Here, we show that the mitochondrial outer-membrane protein MARCH5 positively regulates TLR7 signaling. Ectopic expression or knockdown of MARCH5 enhances or impairs NF-kappa B-mediated gene expression, respectively. MARCH5 interacts specifically with TANK, and this interaction is enhanced by R837 stimulation. MARCH5 catalyzes the K63-linked poly-ubiquitination of TANK on its Lysines 229, 233, 280, 302 and 306, thus impairing the ability of TANK to inhibit TRAF6. Mislocalization of MARCH5 abolishes its action on TANK, revealing the critical role of mitochondria in modulating innate immunity. Arguably, this represents the first study linking mitochondria to TLR signaling.
学科主题	Microbiology; Parasitology; Virology
类目[WOS]	Microbiology ; Parasitology ; Virology
关键词[WOS]	NF-KAPPA-B ; INTERFERON REGULATORY FACTOR-3 ; TOLL-LIKE RECEPTORS ; NEGATIVE REGULATOR ; ANTIVIRAL IMMUNITY ; FACTOR ACTIVATION ; INNATE IMMUNITY ; I INTERFERON ; ADAPTER ; KINASE
收录类别	SCI
语种	英语
WOS记录号	WOS:000291014000040
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/790]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Shi, HX,Liu, X,Wang, Q,et al. Mitochondrial Ubiquitin Ligase MARCH5 Promotes TLR7 Signaling by Attenuating TANK Action[J]. PLOS PATHOGENS,2011,7(5):e1002057-e1002057.
APA	Shi, HX.,Liu, X.,Wang, Q.,Tang, PP.,Liu, XY.,...&Wang, C.(2011).Mitochondrial Ubiquitin Ligase MARCH5 Promotes TLR7 Signaling by Attenuating TANK Action.PLOS PATHOGENS,7(5),e1002057-e1002057.
MLA	Shi, HX,et al."Mitochondrial Ubiquitin Ligase MARCH5 Promotes TLR7 Signaling by Attenuating TANK Action".PLOS PATHOGENS 7.5(2011):e1002057-e1002057.