Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice

	Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice
	Sun, RL; Wang, HY; Yang, XY; Sheng, ZJ; Li, LM; Wang, L; Wang, ZG; Fei, J
刊名	GENETICS AND MOLECULAR RESEARCH
	2011
卷号	10 期号:4 页码:3712-3721
关键词	IL-1 beta IL-6 LPS Zinc finger protein 191
通讯作者	Fei, J (reprint author), Shanghai Res Ctr Model Organisms, Shanghai, Peoples R China.,jfei@tongji.edu.cn
英文摘要	Zinc finger protein 191, ZNF24 and Zfp191 in both humans and mice belong to the SCAN domain subfamily of Kruppel-like zinc finger transcription factors. Previous studies have suggested that Zfp191 is a pleiotropic factor involved in embryonic development, hematopoiesis and tumorigenesis. However, little is known about its target genes or its role in other physiological and pathological processes. We have identified the putative target genes of Zfp191, using an in silico genome-wide scan. Three hundred and fifty-five putative target genes were identified, which were enriched into the pathways of immune response according to the pathway analysis. These targets indicated that Zfp191 may function as a mediator of the immune response. This was verified in mice heterozygous for Zfp191 (Zfp191(+/-)) using a lipopolysaccharide (LPS)-induced endotoxic shock model. After LPS injection, Zfp191(+/-) mice produced significantly less IL-1 beta and IL-6 compared to wild-type mice and were resistant to LPS-induced endotoxic shock. The loss of Zfp191 may suppress systemic inflammation by reducing these cytokine levels during LPS-induced endotoxic shock.
学科主题	Biochemistry & Molecular Biology; Genetics & Heredity
类目[WOS]	Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]	ZINC-FINGER TRANSCRIPTION ; ACTIVATED PROTEIN-KINASE ; EMBRYONIC-DEVELOPMENT ; SCAN DOMAIN ; SEPSIS ; IDENTIFICATION ; EXPRESSION ; REVEALS ; MECHANISMS ; CLONING
收录类别	SCI
语种	英语
WOS记录号	WOS:000300617600144
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/788]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Sun, RL,Wang, HY,Yang, XY,et al. Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice[J]. GENETICS AND MOLECULAR RESEARCH,2011,10(4):3712-3721.
APA	Sun, RL.,Wang, HY.,Yang, XY.,Sheng, ZJ.,Li, LM.,...&Fei, J.(2011).Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice.GENETICS AND MOLECULAR RESEARCH,10(4),3712-3721.
MLA	Sun, RL,et al."Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice".GENETICS AND MOLECULAR RESEARCH 10.4(2011):3712-3721.