Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

	Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques
	Tang, JJ; Li, JG; Qi, W; Qiu, WW; Li, PS; Li, BL; Song, BL
刊名	CELL METABOLISM
	2011
卷号	13 期号:1 页码:44-56
通讯作者	Song, BL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,blsong@sibs.ac.cn
英文摘要	Sterol regulatory element-binding proteins (SREBPs) are major transcription factors activating the expression of genes involved in biosynthesis of cholesterol, fatty acid and triglyceride. In this study, we identified a small molecule, betulin, that specifically inhibited the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig. Inhibition of SREBP by betulin decreased the biosynthesis of cholesterol and fatty acid. In vivo, betulin ameliorated diet-induced obesity, decreased the lipid contents in serum and tissues, and increased insulin sensitivity. Furthermore, betulin reduced the size and improved the stability of atherosclerotic plaques. Our study demonstrates that inhibition SREBP pathway can be employed as a therapeutic strategy to treat metabolic diseases including type II diabetes and atherosclerosis. Betulin, which is abundant in birch bark, could be a leading compound for development of drugs for hyperlipidemia.
学科主题	Cell Biology; Endocrinology & Metabolism
类目[WOS]	Cell Biology ; Endocrinology & Metabolism
关键词[WOS]	STEROL REGULATORY ELEMENT ; RECEPTOR LXR-ALPHA ; FEEDBACK-REGULATION ; LIPID-SYNTHESIS ; LDL RECEPTOR ; CHOLESTEROL ; MICE ; PROTEIN ; LIVER ; REDUCTASE
收录类别	SCI
语种	英语
WOS记录号	WOS:000286967400009
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/725]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Tang, JJ,Li, JG,Qi, W,et al. Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques[J]. CELL METABOLISM,2011,13(1):44-56.
APA	Tang, JJ.,Li, JG.,Qi, W.,Qiu, WW.,Li, PS.,...&Song, BL.(2011).Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques.CELL METABOLISM,13(1),44-56.
MLA	Tang, JJ,et al."Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques".CELL METABOLISM 13.1(2011):44-56.