P-4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth

	P-4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth
	Xu, Q; Yang, GY; Liu, N; Xu, P; Chen, YL; Zhou, Z; Luo, ZG; Ding, XY
刊名	FEBS LETTERS
	2012
卷号	586 期号:13 页码:1803-1812
关键词	P-4-ATPase CDC50 protein Neuronal differentiation Flippase
通讯作者	Ding, XY (reprint author), Chinese Acad Sci, Grad Sch, State Key Lab Cell Biol, Inst Biochem & Cell Biol,SIBS, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xyding@sibs.ac.cn
英文摘要	P-4-ATPases are lipid flippases that transport phospholipids across cellular membranes, playing vital roles in cell function. In humans, the disruption of the P-4-ATPase ATP8A2 gene causes a severe neurological phenotype. Here, we found that Atp8a2 mRNA was highly expressed in PC12 cells, hippocampal neurons and the brain. Overexpression of ATP8A2 increased the length of neurite outgrowth in NGF-induced PC12 cells and in primary cultures of rat hippocampal neurons. Inducing the loss of function of CDC50A in hippocampal neurons via RNA interference reduced neurite outgrowth, and the co-overexpression of CDC50A and ATP8A2 in PC12 cells enhanced NGF-induced neurite outgrowth. These results indicate that ATP8A2, acting in synergy with CDC50A, performs an important role in neurite outgrowth in neurons. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Biophysics; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]	P-TYPE ATPASE ; NERVE GROWTH-FACTOR ; PHOSPHOLIPID TRANSLOCATION ; SUBCELLULAR-LOCALIZATION ; SACCHAROMYCES-CEREVISIAE ; DRS2P ; PROTEIN ; DIFFERENTIATION ; IDENTIFICATION ; ESTABLISHMENT
收录类别	SCI
语种	英语
WOS记录号	WOS:000305405000010
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/671]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Xu, Q,Yang, GY,Liu, N,et al. P-4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth[J]. FEBS LETTERS,2012,586(13):1803-1812.
APA	Xu, Q.,Yang, GY.,Liu, N.,Xu, P.,Chen, YL.,...&Ding, XY.(2012).P-4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth.FEBS LETTERS,586(13),1803-1812.
MLA	Xu, Q,et al."P-4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth".FEBS LETTERS 586.13(2012):1803-1812.