Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring ST13 Gene | |
Zhou, XM; Xie, GL; Wang, SB; Wang, YG; Zhang, KJ; Zheng, S; Chu, L; Xiao, LL; Yu, YM; Zhang, Y | |
刊名 | PLOS ONE |
2012 | |
卷号 | 7期号:10页码:e47566-e47566 |
通讯作者 | Liu, XY (reprint author), Zhejiang Sci Tech Univ, Coll Life Sci, Xinyuan Inst Med & Biotechnol, Hangzhou, Zhejiang, Peoples R China.,xyliu@sibs.ac.cn |
英文摘要 | Cancer Targeting Gene-Viro-Therapy (CTGVT) is constructed by inserting an antitumor gene into an oncolytic virus (OV). It is actually an OV-gene therapy, which has much better antitumor effect than either gene therapy alone or virotherapy alone in our previously published papers. This study is a modification of CTGVT by inserting a colorectal cancer (CRC) specific suppressor gene, ST13, into a CRC specific oncolytic virus, the Ad.CEA.E1A(Delta 24), to construct the Ad.(ST13).CEA.E1A(Delta 24) for increasing the targeting tropism to colorectal cancer and it was briefly named as CTGVT-CRC. Although many studies on CEA promoter and ST13 gene were reported but no construct has been performed to combine both of them as a new strategy for colorectal cancer (CRC) specific therapy. In addition to the CRC specificity, the antitumor effect of Ad.(ST13).CEA.E1A(Delta 24) was also excellent and got nearly complete inhibition (not eradication) of CRC xenograft since ST13 was an effective antitumor gene with less toxicity, and a Chinese patent (No. 201110319434.4) was available for this study. Ad.(ST13).CEA.E1A(Delta 24) caused cell apoptosis through P38 MAPK (i.e. P38) which upregulated CHOP and ATF2 expression. The mitochondrial medicated apoptosis pathway was activated by the increase of caspase 9 and caspase 3 expression. |
学科主题 | Science & Technology - Other Topics |
类目[WOS] | Multidisciplinary Sciences |
关键词[WOS] | APOPTOSIS-INDUCING LIGAND ; CARCINOEMBRYONIC ANTIGEN ; PANCREATIC-CANCER ; TUMOR-SUPPRESSOR ; VIRO-THERAPY ; COLON-CANCER ; TRAIL ; VIROTHERAPY ; CARCINOMA ; PROMOTER |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000309995100134 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/648] |
专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
推荐引用方式 GB/T 7714 | Zhou, XM,Xie, GL,Wang, SB,et al. Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring ST13 Gene[J]. PLOS ONE,2012,7(10):e47566-e47566. |
APA | Zhou, XM.,Xie, GL.,Wang, SB.,Wang, YG.,Zhang, KJ.,...&Liu, XY.(2012).Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring ST13 Gene.PLOS ONE,7(10),e47566-e47566. |
MLA | Zhou, XM,et al."Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring ST13 Gene".PLOS ONE 7.10(2012):e47566-e47566. |
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