Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew (Tupaia belangeri chinensis)

	Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew (Tupaia belangeri chinensis)
	Li, RX; Xu, W; Wang, Z; Liang, B; Wu, JR; Zeng, R
刊名	PROTEIN & CELL
	2012
卷号	3 期号:9 页码:691-700
关键词	proteome Chinese tree shrew phylogenetic tree liver muscle
通讯作者	Zeng, R (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China.,zr@sibs.ac.cn
英文摘要	Valid animal models are useful for studying the pathophysiology of specific disorders, such as neural disease, diabetes and cancer. Previous molecular phylogeny studies indicate that the tree shrew is in the same order as (or a close sister to) primates, and thus may be an ideal model in which to study human disease. In this study, the proteome of liver and muscle tissue in tree the shrew was identified by combining peptide fractionation and LC-MS/MS identification. In total, 2146 proteins were detected, including 1759 proteins in liver samples and 885 proteins in skeletal muscle samples from the tree shrew. Further sub-source analysis revealed that nearly half of the identified proteins (846 proteins and 418 proteins) were derived from human database. In this study, we are the first to describe the characteristics of the proteome from the liver and skeletal muscle of the tree shrew. Phylogenetic tree analysis based on these proteomic data showed that the tree shrew is closer to primates (human) than to glires (the mouse and rat).
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	COMPLETE MITOCHONDRIAL GENOME ; MASS-SPECTROMETRY ; BIOMEDICAL-RESEARCH ; PRIMATES ; MODELS ; IDENTIFICATION ; PROTEINS ; MICE
收录类别	SCI
语种	英语
WOS记录号	WOS:000310532800006
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/638]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Li, RX,Xu, W,Wang, Z,et al. Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew (Tupaia belangeri chinensis)[J]. PROTEIN & CELL,2012,3(9):691-700.
APA	Li, RX,Xu, W,Wang, Z,Liang, B,Wu, JR,&Zeng, R.(2012).Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew (Tupaia belangeri chinensis).PROTEIN & CELL,3(9),691-700.
MLA	Li, RX,et al."Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew (Tupaia belangeri chinensis)".PROTEIN & CELL 3.9(2012):691-700.