The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance

	The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance
	Peng, J; Zhou, JQ
刊名	NUCLEIC ACIDS RESEARCH
	2012
卷号	40 期号:2 页码:581-593
通讯作者	Zhou, JQ (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China.,jqzhou@sibs.ac.cn
英文摘要	Eukaryotic chromosome ends have a DNA-protein complex structure termed telomere. Integrity of telomeres is essential for cell proliferation. Genome-wide screenings for telomere length maintenance genes identified several components of the transcriptional regulator, the Mediator complex. Our work provides evidence that Mediator is involved in telomere length regulation and telomere heterochromatin maintenance. Tail module of Mediator is required for telomere silencing by promoting or stabilizing Sir protein binding and spreading on telomeres. Mediator binds on telomere and may be a component of telomeric chromatin. Our study reveals a specific role of Mediator complex at the heterochromatic telomere and this function is specific to telomeres as it has no effect on the HMR locus.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	RNA-POLYMERASE-II ; DNA-BINDING PROTEIN ; SACCHAROMYCES-CEREVISIAE TELOMERASE ; TRANSCRIPTIONAL ACTIVATION ; SIR2/SIR4 COMPLEX ; IN-VITRO ; LENGTH ; GENE ; ACETYLATION ; GENOME
收录类别	SCI
语种	英语
WOS记录号	WOS:000299095900016
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/553]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Peng, J,Zhou, JQ. The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance[J]. NUCLEIC ACIDS RESEARCH,2012,40(2):581-593.
APA	Peng, J,&Zhou, JQ.(2012).The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance.NUCLEIC ACIDS RESEARCH,40(2),581-593.
MLA	Peng, J,et al."The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance".NUCLEIC ACIDS RESEARCH 40.2(2012):581-593.