Long Noncoding RNAs with snoRNA Ends

	Long Noncoding RNAs with snoRNA Ends
	Yin, QF; Yang, L; Zhang, Y; Xiang, JF; Wu, YW; Carmichael, GG; Chen, LL
刊名	MOLECULAR CELL
	2012
卷号	48 期号:2 页码:219-230
通讯作者	Carmichael, GG (reprint author), Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Stem Cell Inst, Farmington, CT 06030 USA.,carmichael@nso2.uchc.edu ; linglingchen@sibcb.ac.cn
英文摘要	We describe the discovery of sno-IncRNAs, a class of nuclear-enriched intron-derived long noncoding RNAs (IncRNAs) that are processed on both ends by the snoRNA machinery. During exonucleolytic trimming, the sequences between the snoRNAs are not degraded, leading to the accumulation of IncRNAs flanked by snoRNA sequences but lacking 5' caps and 3' poly(A) tails. Such RNAs are widely expressed in cells and tissues and can be produced by either box C/D or box H/ACA snoRNAs. Importantly, the genomic region encoding one abundant class of sno-IncRNAs (15q11-q13) is specifically deleted in Prader-Willi Syndrome (PWS). The PWS region sno-IncRNAs do not colocalize with nucleoli or Cajal bodies, but rather accumulate near their sites of synthesis. These sno-IncRNAs associate strongly with Fox family splicing regulators and alter patterns of splicing. These results thus implicate a previously unannotated class of IncRNAs in the molecular pathogenesis of PWS.
学科主题	Biochemistry & Molecular Biology; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]	SMALL NUCLEOLAR RNA ; PRADER-WILLI-SYNDROME ; MAMMALIAN-CELLS ; STEM-CELLS ; PROTEIN ; NUCLEAR ; INTRON ; FOX-1 ; IDENTIFICATION ; TRANSCRIPTION
收录类别	SCI
语种	英语
WOS记录号	WOS:000310423800008
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/539]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yin, QF,Yang, L,Zhang, Y,et al. Long Noncoding RNAs with snoRNA Ends[J]. MOLECULAR CELL,2012,48(2):219-230.
APA	Yin, QF.,Yang, L.,Zhang, Y.,Xiang, JF.,Wu, YW.,...&Chen, LL.(2012).Long Noncoding RNAs with snoRNA Ends.MOLECULAR CELL,48(2),219-230.
MLA	Yin, QF,et al."Long Noncoding RNAs with snoRNA Ends".MOLECULAR CELL 48.2(2012):219-230.