Human amniotic epithelial cells express specific markers of nerve cells and migrate along the nerve fibers in the corpus callosum

	Human amniotic epithelial cells express specific markers of nerve cells and migrate along the nerve fibers in the corpus callosum
	Wu, ZY; Hu, GZ; Lu, Y; Liu, TJ; Huang, Q; Guo, LH
刊名	NEURAL REGENERATION RESEARCH
	2012
卷号	7 期号:1 页码:41-45
关键词	human amniotic epithelial cells cell transplantation microtubule-associated protein-2 glial fibrillary acidic protein nestin neurotrophin central nervous system injury neural regeneration
通讯作者	Hu, GZ (reprint author), Soochow Univ, Dept Neurosurg, Affiliated Hosp 1, Suzhou 215006, Jiangsu, Peoples R China.,guozhen-hui@163.com ; lhguo@sibs.ac.cn
英文摘要	Human amniotic epithelial cells were isolated from a piece of fresh amnion. Using immunocytochemical methods, we investigated the expression of neuronal phenotypes (microtubule-associated protein-2, glial fibrillary acidic protein and nestin) in human amniotic epithelial cells. The conditioned medium of human amniotic epithelial cells promoted the growth and proliferation of rat glial cells cultured in vitro, and this effect was dose-dependent. Human amniotic epithelial cells were further transplanted into the corpus striatum of healthy adult rats and the grafted cells could integrate with the host and migrate 1-2 mm along the nerve fibers in corpus callosum. Our experimental findings indicate that human amniotic epithelial cells may be a new kind of seed cells for use in neurograft.
学科主题	Cell Biology; Neurosciences & Neurology
类目[WOS]	Cell Biology ; Neurosciences
关键词[WOS]	NEURAL STEM-CELLS ; TRANSPLANTATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000299915000008
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/534]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wu, ZY,Hu, GZ,Lu, Y,et al. Human amniotic epithelial cells express specific markers of nerve cells and migrate along the nerve fibers in the corpus callosum[J]. NEURAL REGENERATION RESEARCH,2012,7(1):41-45.
APA	Wu, ZY,Hu, GZ,Lu, Y,Liu, TJ,Huang, Q,&Guo, LH.(2012).Human amniotic epithelial cells express specific markers of nerve cells and migrate along the nerve fibers in the corpus callosum.NEURAL REGENERATION RESEARCH,7(1),41-45.
MLA	Wu, ZY,et al."Human amniotic epithelial cells express specific markers of nerve cells and migrate along the nerve fibers in the corpus callosum".NEURAL REGENERATION RESEARCH 7.1(2012):41-45.