Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired T(H)17 cell differentiation | |
Li, J; Wei, B; Guo, A; Liu, C; Huang, SC; Du, F; Fan, W; Bao, CD; Pei, G | |
刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
2013 | |
卷号 | 110期号:18页码:7395-7400 |
通讯作者 | Pei, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol,Grad Sch, Shanghai 200031, Peoples R China.,gpei@sibs.ac.cn |
英文摘要 | Rheumatoid arthritis (RA) is an inflammatory disease in which interleukin 17 (IL-17)-producing T helper 17 (T(H)17) cells have been critically involved. We show that in patients with RA, the expression of a multifunctional regulator beta-arrestin1 was significantly up-regulated in peripheral and synovial CD4(+) T cells, which correlated well with active phases of RA. In collagen-induced arthritis, deficiency of beta-arrestin1 ameliorated disease with decreased T(H)17 cell differentiation, proinflammatory cytokine production, synovitis, and cartilage and bone destruction. Further mechanistic study reveals that beta-arrestin1 promoted signal transducer and activator of transcription 3 (STAT3) activation required for T(H)17 cell differentiation through scaffolding the interaction of Janus kinase 1 and STAT3. These findings indicate a critical role for beta-arrestin1 in the pathogenesis of collagen-induced arthritis and T(H)17 cell differentiation and suggest beta-arrestin1 as a potential diagnostic biomarker and therapeutic target for RA. |
学科主题 | Science & Technology - Other Topics |
类目[WOS] | Multidisciplinary Sciences |
关键词[WOS] | HELPER T-CELLS ; RHEUMATOID-ARTHRITIS ; BETA-ARRESTINS ; TH17 CELLS ; STAT3 ; MICE ; INFLAMMATION ; DISEASE ; GENERATION ; INDUCTION |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000318682300062 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/460] |
专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
推荐引用方式 GB/T 7714 | Li, J,Wei, B,Guo, A,et al. Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired T(H)17 cell differentiation[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2013,110(18):7395-7400. |
APA | Li, J.,Wei, B.,Guo, A.,Liu, C.,Huang, SC.,...&Pei, G.(2013).Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired T(H)17 cell differentiation.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,110(18),7395-7400. |
MLA | Li, J,et al."Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired T(H)17 cell differentiation".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110.18(2013):7395-7400. |
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