Let7a inhibits the growth of endometrial carcinoma cells by targeting Aurora-B

	Let7a inhibits the growth of endometrial carcinoma cells by targeting Aurora-B
	Liu, P; Qi, MY; Ma, CB; Lao, GY; Liu, Y; Liu, Y; Liu, YZ
刊名	FEBS LETTERS
	2013
卷号	587 期号:16 页码:2523-2529
关键词	Endometrial carcinoma cell Targeting Aurora-B MicroRNA Let-7a
通讯作者	Ma, CB (reprint author), Changning Matern & Infant Hlth Hosp, Dept Gynecol, Shanghai, Peoples R China.,cbma1966@live.cn
英文摘要	MicroRNAs negatively regulate target gene expression at the post-transcriptional level during carcinogenesis. Recent advances revealed that the expression levels of several miRNAs are up- or down-regulated in endomenial carcinoma (EC). Here we identify dysregulated miRNAs in EC and we elucidate the essential role of let-7a. The expression of 86 miRNAs in EC was found to be different from adjacent normal endometrial tissues. Moreover, miR-let-7 members are down-regulated in EC and let-7 miRNAs are highly associated with endometrial cancer. A functional investigation revealed that let-7a suppressed proliferation of HeLa cells by targeting Aurora-B. Let-7a also antagonizes Aurora-B functions in promoting carcinoma cell proliferation by down-regulating Aurora-B protein level. Let-7a could be applied for gene therapy against endometrial carcinogenesis. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Biophysics; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]	LET-7 MICRORNA FAMILY ; CANCER CELLS ; EXPRESSION ; TUMORIGENESIS ; ONCOGENE ; ADENOCARCINOMA ; SUPPRESSOR ; REPRESSES ; PROGNOSIS ; PROFILES
收录类别	SCI
语种	英语
WOS记录号	WOS:000323458400007
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/455]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liu, P,Qi, MY,Ma, CB,et al. Let7a inhibits the growth of endometrial carcinoma cells by targeting Aurora-B[J]. FEBS LETTERS,2013,587(16):2523-2529.
APA	Liu, P.,Qi, MY.,Ma, CB.,Lao, GY.,Liu, Y.,...&Liu, YZ.(2013).Let7a inhibits the growth of endometrial carcinoma cells by targeting Aurora-B.FEBS LETTERS,587(16),2523-2529.
MLA	Liu, P,et al."Let7a inhibits the growth of endometrial carcinoma cells by targeting Aurora-B".FEBS LETTERS 587.16(2013):2523-2529.