Circular Intronic Long Noncoding RNAs

	Circular Intronic Long Noncoding RNAs
	Zhang, Y; Zhang, XO; Chen, T; Xiang, JF; Yin, QF; Xing, YH; Zhu, SS; Yang, L; Chen, LL
刊名	MOLECULAR CELL
	2013
卷号	51 期号:6 页码:792-806
通讯作者	Yang, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China.,liyang@picb.ac.cn ; linglingchen@sibcb.ac.cn
英文摘要	We describe the identification and characterization of circular intronic long noncoding RNAs in human cells, which accumulate owing to a failure in debranching. The formation of such circular intronic RNAs (ciRNAs) can be recapitulated using expression vectors, and their processing depends on a consensus motif containing a 7 nt GU-rich element near the 50 splice site and an 11 nt C-rich element close to the branchpoint site. In addition, we show that ciRNAs are abundant in the nucleus and have little enrichment for microRNA target sites. Importantly, knockdown of ciRNAs led to the reduced expression of their parent genes. One abundant such RNA, ci-ankrd52, largely accumulates to its sites of transcription, associates with elongation Pol II machinery, and acts as a positive regulator of Pol II transcription. This study thus suggests a cis-regulatory role of noncoding intronic transcripts on their parent coding genes.
学科主题	Biochemistry & Molecular Biology; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]	SMALL NUCLEOLAR RNAS ; POLYMERASE-II ; B2 RNA ; PROTEIN INTERACTIONS ; REGULATORY RNAS ; ANKYRIN REPEAT ; TRANSCRIPTION ; REVEALS ; CELLS ; GENE
收录类别	SCI
语种	英语
WOS记录号	WOS:000330191200009
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/403]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, Y,Zhang, XO,Chen, T,et al. Circular Intronic Long Noncoding RNAs[J]. MOLECULAR CELL,2013,51(6):792-806.
APA	Zhang, Y.,Zhang, XO.,Chen, T.,Xiang, JF.,Yin, QF.,...&Chen, LL.(2013).Circular Intronic Long Noncoding RNAs.MOLECULAR CELL,51(6),792-806.
MLA	Zhang, Y,et al."Circular Intronic Long Noncoding RNAs".MOLECULAR CELL 51.6(2013):792-806.