Generating Hypoimmunogenic Human Embryonic Stem Cells by the Disruption of Beta 2-Microglobulin

	Generating Hypoimmunogenic Human Embryonic Stem Cells by the Disruption of Beta 2-Microglobulin
	Lu, PF; Chen, JJ; He, LXZ; Ren, JT; Chen, HD; Rao, LJ; Zhuang, QG; Li, H; Li, L; Bao, L
刊名	STEM CELL REVIEWS AND REPORTS
	2013
卷号	9 期号:6 页码:806-813
关键词	Beta 2-microglobulin Human leukocyte antigens Hypoimmunogenicity Human embryonic stem cells Immune rejection iPS cells
通讯作者	Xiao, L (reprint author), Zhejiang Univ, Sch Med, 866 Yuhangtang Rd,Nongshenghuan Bldg E,Room 301, Hangzhou 310058, Zhejiang, Peoples R China.,leixiao@sibs.ac.cn
英文摘要	Immune rejection hinders the application of human embryonic stem cells (hESCs) in transplantation therapy. Human leukocyte antigens (HLAs) on the cell surface are the major cause of graft rejection. In this study, we generated HLA class I-deficient hESCs via disruption of beta 2-microglobulin (beta 2m), the light chain of HLA Class I. We found that HLA class I proteins were not present on the cell surface of beta 2m-null hESCs. These cells showed the same pluripotency as wildtype hESCs and demonstrated hypoimmunogenicity. Thus, HLA class I-deficient hESCs might serve as an unlimited cell source for the generation of universally compatible "off-the-shelf" cell grafts, tissues or organs in the future.
学科主题	Cell Biology; Research & Experimental Medicine
类目[WOS]	Cell & Tissue Engineering ; Cell Biology ; Medicine, Research & Experimental
关键词[WOS]	NATURAL-KILLER-CELLS ; T-CELLS ; LINES ; DEFICIENT ; EFFECTORS ; PROTEINS
收录类别	SCI
语种	英语
WOS记录号	WOS:000327386500007
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/402]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Lu, PF,Chen, JJ,He, LXZ,et al. Generating Hypoimmunogenic Human Embryonic Stem Cells by the Disruption of Beta 2-Microglobulin[J]. STEM CELL REVIEWS AND REPORTS,2013,9(6):806-813.
APA	Lu, PF.,Chen, JJ.,He, LXZ.,Ren, JT.,Chen, HD.,...&Xiao, L.(2013).Generating Hypoimmunogenic Human Embryonic Stem Cells by the Disruption of Beta 2-Microglobulin.STEM CELL REVIEWS AND REPORTS,9(6),806-813.
MLA	Lu, PF,et al."Generating Hypoimmunogenic Human Embryonic Stem Cells by the Disruption of Beta 2-Microglobulin".STEM CELL REVIEWS AND REPORTS 9.6(2013):806-813.