Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins

	Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins
	Liu, X; Wang, Q; Chen, W; Wang, C
刊名	CYTOKINE & GROWTH FACTOR REVIEWS
	2013
卷号	24 期号:6 页码:559-570
关键词	Ubiquitin SUMO ISG15 Signal transduction Innate immunity
通讯作者	Wang, C (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,cwang01@sibcb.ac.cn
英文摘要	Protein post-translational modifications (PTMs) are central to the host innate immune regulations. Dynamically, PTMs fine-tune the spatial and temporary responses of immune- and non-immune-cells, in accordance with extracellular and intracellular stresses. Ubiquitin and ubiquitin-like proteins (Ubls) are emerging as the important multi-functional signals, controlling the activation, stability, affinity and location of many signaling proteins. Recent investigations, at the molecular-cellular-animal models, have shed new light on the versatility of the ubiquitin, SUMO and ISG15, for shaping the strength and duration of the innate immune responses. This review summarizes our current knowledge on the functions and regulatory mechanisms of the ubiquitin and Ubls in the innate immunity, the first line of host defense against microbial infection. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]	NF-KAPPA-B ; I INTERFERON INDUCTION ; CELLULAR ANTIVIRAL RESPONSE ; UNANCHORED POLYUBIQUITIN CHAINS ; PATTERN-RECOGNITION RECEPTORS ; TOLL-LIKE RECEPTORS ; NOD-LIKE RECEPTORS ; RIG-I ; NEGATIVE REGULATION ; KINASE COMPLEX
收录类别	SCI
语种	英语
WOS记录号	WOS:000328923900007
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/400]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liu, X,Wang, Q,Chen, W,et al. Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins[J]. CYTOKINE & GROWTH FACTOR REVIEWS,2013,24(6):559-570.
APA	Liu, X,Wang, Q,Chen, W,&Wang, C.(2013).Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins.CYTOKINE & GROWTH FACTOR REVIEWS,24(6),559-570.
MLA	Liu, X,et al."Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins".CYTOKINE & GROWTH FACTOR REVIEWS 24.6(2013):559-570.