Cbx4 regulates the proliferation of thymic epithelial cells and thymus function

	Cbx4 regulates the proliferation of thymic epithelial cells and thymus function
	Liu, B; Liu, YF; Du, YR; Mardaryev, AN; Yang, W; Chen, H; Xu, ZM; Xu, CQ; Zhang, XR; Botchkarev, VA
刊名	DEVELOPMENT
	2013
卷号	140 期号:4 页码:780-788
关键词	Thymic epithelial cell Cbx4 Thymic hypoplasia T-lymphopoiesis p63 (Trp63) Polycomb Epithelial progenitor
通讯作者	Zhang, Y (reprint author), Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100191, Peoples R China.,zhangyu007@bjmu.edu.cn ; glxu@sibcb.ac.cn
英文摘要	Thymic epithelial cells (TECs) are the main component of the thymic stroma, which supports T-cell proliferation and repertoire selection. Here, we demonstrate that Cbx4, a Polycomb protein that is highly expressed in the thymic epithelium, has an essential and non-redundant role in thymic organogenesis. Targeted disruption of Cbx4 causes severe hypoplasia of the fetal thymus as a result of reduced thymocyte proliferation. Cell-specific deletion of Cbx4 shows that the compromised thymopoiesis is rooted in a defective epithelial compartment. Cbx4-deficient TECs exhibit impaired proliferative capacity, and the limited thymic epithelial architecture quickly deteriorates in postnatal mutant mice, leading to an almost complete blockade of T-cell development shortly after birth and markedly reduced peripheral T-cell populations in adult mice. Furthermore, we show that Cbx4 physically interacts and functionally correlates with p63, which is a transcriptional regulator that is proposed to be important for the maintenance of the stemness of epithelial progenitors. Together, these data establish Cbx4 as a crucial regulator for the generation and maintenance of the thymic epithelium and, hence, for thymocyte development.
学科主题	Developmental Biology
类目[WOS]	Developmental Biology
关键词[WOS]	STEM-CELLS ; STRATIFIED EPITHELIA ; PROTEINS ; DIFFERENTIATION ; EXPRESSION ; ORGANOGENESIS ; PROGENITORS ; MECHANISMS ; BMI-1 ; MICE
收录类别	SCI
语种	英语
WOS记录号	WOS:000314405000009
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/382]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liu, B,Liu, YF,Du, YR,et al. Cbx4 regulates the proliferation of thymic epithelial cells and thymus function[J]. DEVELOPMENT,2013,140(4):780-788.
APA	Liu, B.,Liu, YF.,Du, YR.,Mardaryev, AN.,Yang, W.,...&Xu, GL.(2013).Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.DEVELOPMENT,140(4),780-788.
MLA	Liu, B,et al."Cbx4 regulates the proliferation of thymic epithelial cells and thymus function".DEVELOPMENT 140.4(2013):780-788.