Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of Ci(R)

	Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of Ci(R)
	Zhang, Z; Feng, J; Pan, CY; Lv, XD; Wu, WQ; Zhou, ZC; Liu, F; Zhang, L; Zhao, Y
刊名	JOURNAL OF CELL BIOLOGY
	2013
卷号	203 期号:4 页码:575-583
通讯作者	Zhao, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,rayzhang@sibcb.ac.cn ; yunzhao@sibcb.ac.cn
英文摘要	The evolutionarily conserved Hedgehog (Hh) signaling pathway is transduced by the Cubitus interruptus (Ci)/Gli family of transcription factors that exist in two distinct repressor (Ci(R)/Gli(R)) and activator (Ci(A)/Gli(A)) forms. Aberrant activation of Hh signaling is associated with various human cancers, but the mechanism through which Ci(R)/Gli(R) properly represses target gene expression is poorly understood. Here, we used Drosophila melanogaster and zebrafish models to define a repressor function of Atrophin (Atro) in Hh signaling. Atro directly bound to Ci through its C terminus. The N terminus of Atro interacted with a histone deacetylase, Rpd3, to recruit it to a Ci-binding site at the decapentaplegic (dpp) locus and reduce dpp transcription through histone acetylation regulation. The repressor function of Atro in Hh signaling was dependent on Ci. Furthermore, Rerea, a homologue of Atro in zebrafish, repressed the expression of Hh-responsive genes. We propose that the Atro Rpd3 complex plays a conserved role to function as a Ci(R) corepressor.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	PROTEIN-KINASE-A ; CUBITUS-INTERRUPTUS ; GROWTH-FACTOR ; TARGET GENES ; DROSOPHILA ; FORMS ; TRANSDUCTION ; ACTIVATOR ; HOMOLOG ; PATHWAY
收录类别	SCI
语种	英语
WOS记录号	WOS:000327578700004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/370]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, Z,Feng, J,Pan, CY,et al. Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of Ci(R)[J]. JOURNAL OF CELL BIOLOGY,2013,203(4):575-583.
APA	Zhang, Z.,Feng, J.,Pan, CY.,Lv, XD.,Wu, WQ.,...&Zhao, Y.(2013).Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of Ci(R).JOURNAL OF CELL BIOLOGY,203(4),575-583.
MLA	Zhang, Z,et al."Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of Ci(R)".JOURNAL OF CELL BIOLOGY 203.4(2013):575-583.