Functional Analysis of Long Noncoding RNAs in Development and Disease

	Functional Analysis of Long Noncoding RNAs in Development and Disease
	Chen, LL; Zhao, JC
刊名	SYSTEMS BIOLOGY OF RNA BINDING PROTEINS
	2014
卷号	825 期号:1 页码:129-158
关键词	Epigenetics Long noncoding RNA Xist sno-lncRNA Cancer RIP-seq CLIP-seq Chart ChIRP
通讯作者	Chen, LL (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,linglingchen@sibcb.ac.cn ; czhao@sanfordburnham.org
英文摘要	Once viewed as part of the "dark matter" of genome, long noncoding RNAs (lncRNAs), which are mRNA-like but lack open reading frames, have emerged as an integral part of the mammalian transcriptome. Recent work demonstrated that lncRNAs play multiple structural and functional roles, and their analysis has become a new frontier in biomedical research. In this chapter, we provide an overview of different lncRNA families, describe methodologies available to study lncRNA-protein and lncRNA-DNA interactions systematically, and use well-studied lncRNAs as examples to illustrate their functional importance during normal development and in disease states.
学科主题	Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology
类目[WOS]	Biology ; Mathematical & Computational Biology
关键词[WOS]	X-CHROMOSOME INACTIVATION ; GENOME-WIDE IDENTIFICATION ; H3 LYSINE-27 METHYLATION ; PRADER-WILLI-SYNDROME ; EMBRYONIC STEM-CELLS ; XIST RNA ; BINDING PROTEIN ; GENE-EXPRESSION ; A-REPEAT ; METHYLTRANSFERASE ACTIVITY
收录类别	SCI
语种	英语
WOS记录号	WOS:000350418400005
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/304]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chen, LL,Zhao, JC. Functional Analysis of Long Noncoding RNAs in Development and Disease[J]. SYSTEMS BIOLOGY OF RNA BINDING PROTEINS,2014,825(1):129-158.
APA	Chen, LL,&Zhao, JC.(2014).Functional Analysis of Long Noncoding RNAs in Development and Disease.SYSTEMS BIOLOGY OF RNA BINDING PROTEINS,825(1),129-158.
MLA	Chen, LL,et al."Functional Analysis of Long Noncoding RNAs in Development and Disease".SYSTEMS BIOLOGY OF RNA BINDING PROTEINS 825.1(2014):129-158.