The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus | |
Zhang, H; Li, XY; Guo, J; Li, L; Chang, C; Li, YY; Bian, C; Xu, K; Chen, HL; Sun, B | |
刊名 | JOURNAL OF GENERAL VIROLOGY
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2014 | |
卷号 | 95期号:1页码:779-786 |
通讯作者 | Sun, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China.,hlchen1@yahoo.com ; bsun@sibs.ac.cn |
英文摘要 | Human infection by H7N9 influenza virus was first identified in China in March 2013. As of 12 August 2013, a total of 135 documented cases with 44 fatalities had been reported. Genetic and laboratory analyses of the novel H7N9 viruses isolated from patients indicate that these viruses possess several polymerase gene mutations previously associated with human adaptation and potential pandemic capabilities. However, the function of these mutations in the emergence and pathogenicity of the viruses is not well known. In this study, we demonstrate that the PB2 E627K mutation, which occurs in over 70% of the H7N9 patient isolates, promotes the replication of H7N9 virus by enhancing PB2 polymerase activity and enhances virulence in mice. Our results show the PB2 E627K mutation has played an important role in this H7N9 influenza outbreak and in the pathogenicity of the H7N9 virus. |
学科主题 | Biotechnology & Applied Microbiology; Virology |
类目[WOS] | Biotechnology & Applied Microbiology ; Virology |
关键词[WOS] | HUMAN-CELLS ; A VIRUS ; VIRAL POLYMERASE ; BRITISH-COLUMBIA ; HUMAN INFECTION ; HUMAN ILLNESS ; HOST-RANGE ; TRANSMISSION ; ADAPTATION ; FERRETS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000338177700002 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/301] ![]() |
专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
推荐引用方式 GB/T 7714 | Zhang, H,Li, XY,Guo, J,et al. The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus[J]. JOURNAL OF GENERAL VIROLOGY,2014,95(1):779-786. |
APA | Zhang, H.,Li, XY.,Guo, J.,Li, L.,Chang, C.,...&Sun, B.(2014).The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus.JOURNAL OF GENERAL VIROLOGY,95(1),779-786. |
MLA | Zhang, H,et al."The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus".JOURNAL OF GENERAL VIROLOGY 95.1(2014):779-786. |
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