IL-1 beta-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis

	IL-1 beta-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis
	Wang, L; Zhang, LF; Wu, J; Xu, SJ; Xu, YY; Li, DS; Lou, JT; Liu, MF
刊名	CANCER RESEARCH
	2014
卷号	74 期号:17 页码:4720-4730
通讯作者	Lou, JT (reprint author), Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Shanghai 200030, Peoples R China.,loujiatao@126.com ; mfliu@sibcb.ac.cn
英文摘要	Inflammatory stimuli clearly contribute to lung cancer development and progression, but the underlying pathogenic mechanisms are not fully understood. We found that the proinflammatory cytokine IL-1 beta is dramatically elevated in the serum of patients with non-small cell lung cancer (NSCLC). in vitro studies showed that IL-1 beta promoted the proliferation and migration of NSCLC cells. Mechanistically, lL-1 beta acted through the COX2-IIIFl alpha pathway to repress the expression of microRNA-101 (miR-101), a microRNA with an established role in tumor suppression. Lin28B was identified as critical effector target of miR-101 with its repression oflin28B, a critical aspect of tumor suppression. Overall, IL-1 beta upregulated Lin28B by downregulating miR-101. Interestingly, cyclooxygenase-2 inhibition by aspirin or celecoxib abrogated IL-1 beta-mediated repression of miR-101 and IL-1 beta-mediated activation of Lin28B along with their stimulatory effects on NSCLC cell proliferation and migration. Together, our findings defined an IL-1 beta-rniR-101-Lin28B pathway as a novel regulatory axis of pathogenic inflammatory signaling in NSCLC. (C) 2014 AACR.
学科主题	Oncology
类目[WOS]	Oncology
关键词[WOS]	BREAST-CANCER ; TUMOR PROGRESSION ; LET-7 ; EXPRESSION ; ASPIRIN ; CELLS ; LIN28 ; PROLIFERATION ; ASSOCIATION ; MECHANISMS
收录类别	SCI
语种	英语
WOS记录号	WOS:000341833300016
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/258]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wang, L,Zhang, LF,Wu, J,et al. IL-1 beta-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis[J]. CANCER RESEARCH,2014,74(17):4720-4730.
APA	Wang, L.,Zhang, LF.,Wu, J.,Xu, SJ.,Xu, YY.,...&Liu, MF.(2014).IL-1 beta-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis.CANCER RESEARCH,74(17),4720-4730.
MLA	Wang, L,et al."IL-1 beta-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis".CANCER RESEARCH 74.17(2014):4720-4730.