Characterization of a micro-roughened TiO2/ZrO2 coating: mechanical properties and HBMSC responses in vitro | |
Si, JW; Zhang, JJ; Liu, S; Zhang, WB; Yu, DD; Wang, XD; Guo, LH; Shen, SGF | |
刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
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2014 | |
卷号 | 46期号:7页码:572-581 |
关键词 | plasma spraying titanium dioxide zirconia mechanical property human bone mesenchymal stem cell osteogenesis |
通讯作者 | Guo, LH (reprint author), Shanghai United Stem Cell Biotechnol Co Ltd, Shanghai 200333, Peoples R China.,guolihe@cell-star.com.cn ; maxillofacsurg@163.com |
英文摘要 | Previous studies have shown that using ZrO2 as a second phase to bioceramics can significantly increase the bonding strength of plasma-sprayed composite material. In the present study, micro-roughened titanium dioxide/zirconia (TiO2/ZrO2) (30 wt% ZrO2) coating and TiO2 coating were plasma-sprayed onto Ti plates. The micro-structural characteristics and mechanical properties of both coatings were investigated. Furthermore, the biological behavior and osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMSCs) on both TiO2/ZrO2 and TiO2 coatings were compared. The results indicated that the shear bond strength and microhardness of TiO2/ZrO2 coating were statistically higher than those of TiO2 coating. Scanning electron microscope observation revealed that more irregularly shaped protuberances and denser pores were formed on the surface of TiO2/ZrO2 coating compared with those of TiO2 coating. Further comparative analysis of HBMSC proliferation and osteogenic differentiation on both coatings showed that significantly higher cellular alkaline phosphatase activity and expression levels of Runx2 and Osterix at day 10 after osteogenic culture were found on TiO2/ZrO2 coating compared with TiO2 coating, while no statistically significant difference in cell proliferation and extracellular calcium deposition was observed. The present study suggests that TiO2/ZrO2 coating may be favorable for dental implant applications. |
学科主题 | Biochemistry & Molecular Biology; Biophysics |
类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
关键词[WOS] | MESENCHYMAL STEM-CELLS ; COMPOSITE COATINGS ; OSTEOBLAST DIFFERENTIATION ; STABILIZED ZIRCONIA ; CERAMIC COMPOSITES ; GLASS-CERAMICS ; TITANIUM ; MICROSTRUCTURE ; SURFACE ; VIVO |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000339115500006 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/210] ![]() |
专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
推荐引用方式 GB/T 7714 | Si, JW,Zhang, JJ,Liu, S,et al. Characterization of a micro-roughened TiO2/ZrO2 coating: mechanical properties and HBMSC responses in vitro[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2014,46(7):572-581. |
APA | Si, JW.,Zhang, JJ.,Liu, S.,Zhang, WB.,Yu, DD.,...&Shen, SGF.(2014).Characterization of a micro-roughened TiO2/ZrO2 coating: mechanical properties and HBMSC responses in vitro.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,46(7),572-581. |
MLA | Si, JW,et al."Characterization of a micro-roughened TiO2/ZrO2 coating: mechanical properties and HBMSC responses in vitro".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 46.7(2014):572-581. |
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