Hsa-miR-132 Regulates Apoptosis in Non-Small Cell Lung Cancer Independent of Acetylcholinesterase

	Hsa-miR-132 Regulates Apoptosis in Non-Small Cell Lung Cancer Independent of Acetylcholinesterase
	Zhang, B; Lu, L; Zhang, XJ; Ye, WY; Wu, J; Xi, QL; Zhang, XJ
刊名	JOURNAL OF MOLECULAR NEUROSCIENCE
	2014
卷号	53 期号:3 页码:335-344
关键词	Hsa-miR-132 Apoptosis Non-small cell lung cancer Acetylcholinesterase
通讯作者	Zhang, XJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,xjzhang@sibcb.ac.cn
英文摘要	MiR-132 is enriched in the central nerve system and is thought to be involved in neuronal development, maturation and function, and to be associated with several neurological disorders including Alzheimer's disease. In addition to its documented neuronal functions, an emerging role for miR-132 in tumorigenesis has been suggested. Recently, hsa-miR-132 was shown to be modulated in different tumor types. However, its role in non-small cell lung cancer (NSCLC) remains unclear. Here, we show that hsa-miR-132 can initiate apoptosis in NSCLC cells to dramatically attenuate tumor formation in nude mice independent of its effect on the proliferation/apoptosis-associated gene, acetylcholinesterase (AChE). Interestingly, hsa-miR-132 has no pro-apoptotic effect in normal pulmonary trachea epithelium. Taken together, these results suggest that hsa-miR-132 represses NSCLC growth by inducing apoptosis independent of AChE.
学科主题	Biochemistry & Molecular Biology; Neurosciences & Neurology
类目[WOS]	Biochemistry & Molecular Biology ; Neurosciences
关键词[WOS]	ADJUVANT THERAPY ; GENETIC-CONTROL ; DISEASE ; DEATH ; EXPRESSION ; CASPASES ; MECHANISMS ; DROSOPHILA ; INDUCTION ; MICRORNAS
收录类别	SCI
语种	英语
WOS记录号	WOS:000339956700008
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/156]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, B,Lu, L,Zhang, XJ,et al. Hsa-miR-132 Regulates Apoptosis in Non-Small Cell Lung Cancer Independent of Acetylcholinesterase[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2014,53(3):335-344.
APA	Zhang, B.,Lu, L.,Zhang, XJ.,Ye, WY.,Wu, J.,...&Zhang, XJ.(2014).Hsa-miR-132 Regulates Apoptosis in Non-Small Cell Lung Cancer Independent of Acetylcholinesterase.JOURNAL OF MOLECULAR NEUROSCIENCE,53(3),335-344.
MLA	Zhang, B,et al."Hsa-miR-132 Regulates Apoptosis in Non-Small Cell Lung Cancer Independent of Acetylcholinesterase".JOURNAL OF MOLECULAR NEUROSCIENCE 53.3(2014):335-344.