Identification of multipotent mammary stemcells by protein C receptor expression

	Identification of multipotent mammary stemcells by protein C receptor expression
	Wang, DS; Cai, CG; Dong, XB; Yu, QC; Zhang, XO; Yang, L; Zeng, YA
刊名	NATURE
	2015
卷号	517 期号:7532 页码:81-U201
通讯作者	Zeng, YA (reprint author), Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,yzeng@sibcb.ac.cn
英文摘要	The mammary gland is composed of multiple types of epithelial cells, which are generated by mammary stem cells (MaSCs) residing at the top of the hierarchy(1,2). However, the existence of these multi-potent MaSCs remains controversial and the nature of such cells is unknown(3,4). Here we demonstrate that protein C receptor (Procr), a novel Wnt target in the mammary gland, marks a unique population of multipotent mouse MaSCs. Procr-positive cells localize to the basal layer, exhibit epithelial-to-mesenchymal transition characteristics, and express low levels of basal keratins. Procr-expressing cells have a high regenerative capacity in transplantation assays and differentiate into all lineages of the mammary epithelium by lineage tracing. These results define a novel multipotent mammary stem cell population that could be important in the initiation of breast cancer.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	STEM-CELLS ; WNT PROTEINS ; GLAND ; LINEAGES ; MOUSE ; BASAL ; GENE
收录类别	SCI
语种	英语
WOS记录号	WOS:000347178400039
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/102]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wang, DS,Cai, CG,Dong, XB,et al. Identification of multipotent mammary stemcells by protein C receptor expression[J]. NATURE,2015,517(7532):81-U201.
APA	Wang, DS.,Cai, CG.,Dong, XB.,Yu, QC.,Zhang, XO.,...&Zeng, YA.(2015).Identification of multipotent mammary stemcells by protein C receptor expression.NATURE,517(7532),81-U201.
MLA	Wang, DS,et al."Identification of multipotent mammary stemcells by protein C receptor expression".NATURE 517.7532(2015):81-U201.