Discovery of New Candidate Genes Related to Brain Development Using Protein Interaction Information

	Discovery of New Candidate Genes Related to Brain Development Using Protein Interaction Information
	Chen, L; Chu, C; Kong, XY; Huang, T; Cai, YD
刊名	PLOS ONE
	2015
卷号	10 期号:1 页码:e0118003-e0118003
通讯作者	Huang, T (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China.,tohuangtao@126.com ; cai_yud@126.com
英文摘要	Human brain development is a dramatic process composed of a series of complex and fine-tuned spatiotemporal gene expressions. A good comprehension of this process can assist us in developing the potential of our brain. However, we have only limited knowledge about the genes and gene functions that are involved in this biological process. Therefore, a substantial demand remains to discover new brain development-related genes and identify their biological functions. In this study, we aimed to discover new brain-development related genes by building a computational method. We referred to a series of computational methods used to discover new disease-related genes and developed a similar method. In this method, the shortest path algorithm was executed on a weighted graph that was constructed using protein-protein interactions. New candidate genes fell on at least one of the shortest paths connecting two known genes that are related to brain development. A randomization test was then adopted to filter positive discoveries. Of the final identified genes, several have been reported to be associated with brain development, indicating the effectiveness of the method, whereas several of the others may have potential roles in brain development.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	NEURAL DEVELOPMENT ; INTERACTION NETWORK ; ALZHEIMER-DISEASE ; CCR4-NOT COMPLEX ; MESSENGER-RNA ; HORMONE GHRH ; MOUSE-BRAIN ; EXPRESSION ; PREDICTION ; SECRETIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000350680700111
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/4]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chen, L,Chu, C,Kong, XY,et al. Discovery of New Candidate Genes Related to Brain Development Using Protein Interaction Information[J]. PLOS ONE,2015,10(1):e0118003-e0118003.
APA	Chen, L,Chu, C,Kong, XY,Huang, T,&Cai, YD.(2015).Discovery of New Candidate Genes Related to Brain Development Using Protein Interaction Information.PLOS ONE,10(1),e0118003-e0118003.
MLA	Chen, L,et al."Discovery of New Candidate Genes Related to Brain Development Using Protein Interaction Information".PLOS ONE 10.1(2015):e0118003-e0118003.