Estrogenic and Neuroprotective Properties of Scutellarin from Erigeron breviscapus: A Drug against Postmenopausal Symptoms and Alzheimer's Disease

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Estrogenic and Neuroprotective Properties of Scutellarin from Erigeron breviscapus: A Drug against Postmenopausal Symptoms and Alzheimer's Disease
	Zhu, Judy T. T.1,2; Choi, Roy C. Y.1,2; Li, Jun 1,2; Xie, Heidi Q. H.1,2; Bi, Cathy W. C.1,2; Cheung, Anna W. H.1,2; Dong, Tina T. X.1,2; Jiang, Zhi Y.3; Chen, Ji J.3; Tsim, Karl W. K.1,2
刊名	PLANTA MEDICA
	2009-11-01
卷号	75 期号:14 页码:1489-1493
关键词	beta-amyloid scutellarin Erigeron breviscapus Compositae estrogen neuroprotection
英文摘要	Besides the classical hormonal effect, estrogen possesses neuroprotective effects in the brain, which leads to the searching of novel treatments for neurodegenerative diseases such as Alzheimer's disease. Scutellarin is a major flavone derived from Herba Erigerontis, a Chinese medicine derived from Erigeron breviscapus, which has been shown here to possess both estrogenic and neuroprotective properties. Scutellarin showed the estrogenic effects by activating the estrogen responsive elements and phosphorylation of estrogen receptor alpha in cultured MCF-7 cells: the activation was in a dose-dependent manner. On the other hand, scutellarin inhibited the aggregation of beta-amyloid in vitro, and prevented the cell death mediated by beta-amyloid when applied to cultured neuronal PC12 cells. These results therefore suggested that Herba Erigerontis and its component scutellarin might have therapeutic effects against postmenopausal symptoms and Alzheimer's disease.
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	MOLECULAR-MECHANISMS ; REPLACEMENT THERAPY ; PC12 CELLS ; FLAVONOIDS ; CHALLENGES ; WOMEN ; BETA
收录类别	SCI
语种	英语
WOS记录号	WOS:000272183500005
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/23886]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China 2.Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Hong Kong, Peoples R China 3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Judy T. T.,Choi, Roy C. Y.,Li, Jun,et al. Estrogenic and Neuroprotective Properties of Scutellarin from Erigeron breviscapus: A Drug against Postmenopausal Symptoms and Alzheimer's Disease[J]. PLANTA MEDICA,2009,75(14):1489-1493.
APA	Zhu, Judy T. T..,Choi, Roy C. Y..,Li, Jun.,Xie, Heidi Q. H..,Bi, Cathy W. C..,...&Tsim, Karl W. K..(2009).Estrogenic and Neuroprotective Properties of Scutellarin from Erigeron breviscapus: A Drug against Postmenopausal Symptoms and Alzheimer's Disease.PLANTA MEDICA,75(14),1489-1493.
MLA	Zhu, Judy T. T.,et al."Estrogenic and Neuroprotective Properties of Scutellarin from Erigeron breviscapus: A Drug against Postmenopausal Symptoms and Alzheimer's Disease".PLANTA MEDICA 75.14(2009):1489-1493.