Synthesis, relaxivity, and T-1 relaxation enhancement of binuclear gadolinium(III) complexes based on DTPA or EDTA and long-chain alkyl esters of L-lysine

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Synthesis, relaxivity, and T-1 relaxation enhancement of binuclear gadolinium(III) complexes based on DTPA or EDTA and long-chain alkyl esters of L-lysine
	Yu, Kaichao ; Hamdan, Yousef ; Wan, Fuxian ; Li, Yinxia ; Huang, Kaixun ; Zhou, Jinlan
刊名	AUSTRALIAN JOURNAL OF CHEMISTRY
	2007
卷号	60 期号:3 页码:218-222
英文摘要	Eight novel diamino-ester ligands were synthesized by amidation reaction of long-chain alkyl esters of L-lysine with diethylenetriamine pentaacetic acid monoanhydride or ethylenediamine tetraacetic acid monoanhydride. The corresponding dimeric Gd(III) complexes were obtained by treating these ligands with GdCl3 center dot 6H(2)O. All ligands and complexes were characterized by H-1 NMR, FT-IR, and elemental analysis. The longitudinal relaxation time (T-1) was measured, and all relaxivity values (R-1) of these dimeric Gd(III) complexes are higher than that of Magnivest (Gd-DTPA). One of these complexes, possessing the highest relaxivity in the DTPA series, was chosen to test the acute toxicity and T-1-weighted imaging. It was found that this dimeric Gd(III) complex exhibits no acute toxicity, and offers highly enhanced MRI signal and increases intention time in the rat liver tissue compared to Magnivest.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	CONTRAST AGENTS ; NMR
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000245341700013
公开日期	2015-08-18
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/4892]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Huazhong Univ Sci & Technol, Dept Chem, Wuhan 430074, Peoples R China 2.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Yu, Kaichao,Hamdan, Yousef,Wan, Fuxian,et al. Synthesis, relaxivity, and T-1 relaxation enhancement of binuclear gadolinium(III) complexes based on DTPA or EDTA and long-chain alkyl esters of L-lysine[J]. AUSTRALIAN JOURNAL OF CHEMISTRY,2007,60(3):218-222.
APA	Yu, Kaichao,Hamdan, Yousef,Wan, Fuxian,Li, Yinxia,Huang, Kaixun,&Zhou, Jinlan.(2007).Synthesis, relaxivity, and T-1 relaxation enhancement of binuclear gadolinium(III) complexes based on DTPA or EDTA and long-chain alkyl esters of L-lysine.AUSTRALIAN JOURNAL OF CHEMISTRY,60(3),218-222.
MLA	Yu, Kaichao,et al."Synthesis, relaxivity, and T-1 relaxation enhancement of binuclear gadolinium(III) complexes based on DTPA or EDTA and long-chain alkyl esters of L-lysine".AUSTRALIAN JOURNAL OF CHEMISTRY 60.3(2007):218-222.