Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma
	Liu, Yanchun1 ; Yang, Hui 2; Chen, Tianxing 2; Luo, Yongbin 1; Xu, Zheyuan 3; Li, Ying 2; Yang, Jiahui 1
刊名	PLOS ONE
	2015-05-15
卷号	10 期号:5 页码:e0127092
通讯作者	Yang,JH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming,Yunnan,Peoples R China. ; yangjiahui@mail.kib.ac.cn
英文摘要	Receptor tyrosine kinase ROR1, an embryonic protein involved in organogenesis, is expressed in certain hematological malignancies and solid tumors, but is generally absent in adult tissues. This makes the protein an ideal drug target for cancer therapy. In order to assess the suitability of ROR1 as a cell surface antigen for targeted therapy of lung adenocarcinoma, we carried out a comprehensive analysis of ROR1 protein expression in human lung adenocarcinoma tissues and cell lines. Our data show that ROR1 protein is selectively expressed on lung adenocarcinoma cells, but do not support the hypothesis that expression levels of ROR1 are associated with aggressive disease. However silencing of ROR1 via siRNA treatment significantly down-regulates the activity of the PI3K/AKT/mTOR signaling pathway. This is associated with significant apoptosis and anti-proliferation of tumor cells. We found ROR1 protein expressed in lung adenocarcinoma but almost absent in tumor-adjacent tissues of the patients. The finding of ROR1-mediated proliferation signals in both tyrosine kinase inhibitor (TKI)-sensitive and -resistant tumor cells provides encouragement to develop ROR1-directed targeted therapy in lung adenocarcinoma, especially those with TKI resistance.
学科主题	Multidisciplinary Sciences
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	CHRONIC LYMPHOCYTIC-LEUKEMIA ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; CHIMERIC ANTIGEN RECEPTOR ; CLL CELLS ; MONOCLONAL-ANTIBODIES ; CANCER STATISTICS ; NEVER SMOKERS ; T-CELLS ; EGFR ; MUTATIONS
收录类别	SCI
语种	英语
WOS记录号	WOS:000354916100128
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/21356]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.First Peoples Hosp Yunnan Prov, Dept Pathol, Kunming, Yunnan, Peoples R China 3.First Peoples Hosp Yunnan Prov, Dept Thorac Surg, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yanchun,Yang, Hui,Chen, Tianxing,et al. Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma[J]. PLOS ONE,2015,10(5):e0127092.
APA	Liu, Yanchun.,Yang, Hui.,Chen, Tianxing.,Luo, Yongbin.,Xu, Zheyuan.,...&Yang, Jiahui.(2015).Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma.PLOS ONE,10(5),e0127092.
MLA	Liu, Yanchun,et al."Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma".PLOS ONE 10.5(2015):e0127092.