Targeting cancer with sesterterpenoids: the new potential antitumor drugs

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Targeting cancer with sesterterpenoids: the new potential antitumor drugs
	Zhang, Caiguo 1; Liu, Yan 2
刊名	JOURNAL OF NATURAL MEDICINES
	2015-07-01
卷号	69 期号:3 页码:255-266
关键词	Terpenoids Sesterterpenoids Cancer therapy Structure-activity relationship
通讯作者	Liu,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Photochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; caiguo.zhang@ucdenver.edu ; liuyan@mail.kib.ac.cn
英文摘要	Cancer remains a major cause of death in the world to date. A variety of anticancer drugs have been used in clinical chemotherapy, acting on the particular oncogenic abnormalities that are responsible for malignant transformation and progression. Interestingly, some of these anticancer drugs are developed from natural sources such as plants, marine organisms, and microorganisms. Over the past decades, a family of naturally occuring molecules, namely sesterterpenoids, has been isolated from different organisms and they exhibit significant potential in the inhibition of tumor cells in vitro, while the molecular targets of these compounds and their functional mechanisms are still obscure. In this review, we summarize and discuss the functions of these sesterterpenoids in the inhibition of cancer cells. Moreover, we also highlight and discuss chemical structure-activity relationships of some compounds, demonstrating their pervasiveness and importance in cancer therapy.
学科主题	Chemistry, Medicinal; Pharmacology & Pharmacy
类目[WOS]	Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	SPONGE RHABDASTRELLA-GLOBOSTELLATA ; MARINE SPONGE ; CYTOTOXIC SESTERTERPENES ; BIOACTIVE SESTERTERPENES ; MANOALIDE DERIVATIVES ; HASLEA-OSTREARIA ; NATURAL-PRODUCTS ; DNA-POLYMERASES ; GENUS FUSARIUM ; HYRTIOS-ERECTA
收录类别	SCI
语种	英语
WOS记录号	WOS:000355875800001
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/21329]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Univ Colorado, Sch Med, Dept Biochem & Mol Genet, Aurora, CO 80045 USA 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Photochem & Plant Resources West Ch, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Caiguo,Liu, Yan. Targeting cancer with sesterterpenoids: the new potential antitumor drugs[J]. JOURNAL OF NATURAL MEDICINES,2015,69(3):255-266.
APA	Zhang, Caiguo,&Liu, Yan.(2015).Targeting cancer with sesterterpenoids: the new potential antitumor drugs.JOURNAL OF NATURAL MEDICINES,69(3),255-266.
MLA	Zhang, Caiguo,et al."Targeting cancer with sesterterpenoids: the new potential antitumor drugs".JOURNAL OF NATURAL MEDICINES 69.3(2015):255-266.