Mesoporous titania based yolk-shell nanoparticles as multifunctional theranostic platforms for SERS imaging and chemo-photothermal treatment

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	Mesoporous titania based yolk-shell nanoparticles as multifunctional theranostic platforms for SERS imaging and chemo-photothermal treatment
	Zhang, Weiwei 1,2; Wang, Yunqing2 ; Sun, Xiuyan 1; Wang, Wenhai2 ; Chen, Lingxin2
刊名	NANOSCALE
	2014
卷号	6 期号:23 页码:14514-14522
关键词	ENHANCED RAMAN-SCATTERING SILICA/TITANIA HOLLOW NANOPARTICLES SILICA CORE-SHELL GOLD NANORODS PHOTODYNAMIC THERAPY DRUG-DELIVERY PARTICLES TAGS
ISSN号	2040-3364
通讯作者	Wang, YQ (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. yqwang@yic.ac.cn ; lxchen@yic.ac.cn
产权排序	[Zhang, Weiwei; Sun, Xiuyan] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; [Zhang, Weiwei; Wang, Yunqing; Wang, Wenhai; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
中文摘要	Recently surface-enhanced Raman scattering (SERS) imaging guided theranostic nanoplatforms have attracted considerable attention. Herein, we developed novel yolk-shell gold nanorod@void@mesoporous titania nanoparticles (AuNR@void@mTiO(2) NPs) for simultaneous SERS imaging and chemo-photothermal therapy. Our work showed three highlighted features: first, we proposed a facile and versatile "up to down" SERS labeling strategy for the drug delivery system, in which "empty carriers" were pre-synthesized, followed by co-loading of Raman reporters on AuNR and anti-cancer drug doxorubicin (DOX) in mTiO(2) in sequence. The acquired SERS signal was strong enough for tracking NPs at both living cells and mice levels. Second, we selected mTiO(2) as a novel drug loading material instead of the widely used mesoporous silica (mSiO(2)). The mTiO(2) shared satisfactory drug loading and release behavior as mSiO(2) but it was chemically inert. This property not only provided a facile way to form a yolk-shell structure but also rendered it with superior structural stability in a biological system. Third, the near infrared (NIR) light absorbing property of the AuNR SERS substrate was also explored for drug release regulation and photothermal treatment. Significantly greater MCF-7 cell killing was observed when treated together with DOX-loaded NPs and NIR laser irradiation, attributable to the synergistic chemo-thermal therapeutic effect. Our results indicated the established SERS labeled yolk-shell NP as a promising theranostic platform and suggested its potential in vivo applications.
英文摘要	Recently surface-enhanced Raman scattering (SERS) imaging guided theranostic nanoplatforms have attracted considerable attention. Herein, we developed novel yolk-shell gold nanorod@void@mesoporous titania nanoparticles (AuNR@void@mTiO(2) NPs) for simultaneous SERS imaging and chemo-photothermal therapy. Our work showed three highlighted features: first, we proposed a facile and versatile "up to down" SERS labeling strategy for the drug delivery system, in which "empty carriers" were pre-synthesized, followed by co-loading of Raman reporters on AuNR and anti-cancer drug doxorubicin (DOX) in mTiO(2) in sequence. The acquired SERS signal was strong enough for tracking NPs at both living cells and mice levels. Second, we selected mTiO(2) as a novel drug loading material instead of the widely used mesoporous silica (mSiO(2)). The mTiO(2) shared satisfactory drug loading and release behavior as mSiO(2) but it was chemically inert. This property not only provided a facile way to form a yolk-shell structure but also rendered it with superior structural stability in a biological system. Third, the near infrared (NIR) light absorbing property of the AuNR SERS substrate was also explored for drug release regulation and photothermal treatment. Significantly greater MCF-7 cell killing was observed when treated together with DOX-loaded NPs and NIR laser irradiation, attributable to the synergistic chemo-thermal therapeutic effect. Our results indicated the established SERS labeled yolk-shell NP as a promising theranostic platform and suggested its potential in vivo applications.
学科主题	Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]	ENHANCED RAMAN-SCATTERING ; SILICA/TITANIA HOLLOW NANOPARTICLES ; SILICA CORE-SHELL ; GOLD NANORODS ; PHOTODYNAMIC THERAPY ; DRUG-DELIVERY ; PARTICLES ; TAGS
收录类别	SCI
语种	英语
WOS记录号	WOS:000344997600056
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/8774]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位	1.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Weiwei,Wang, Yunqing,Sun, Xiuyan,et al. Mesoporous titania based yolk-shell nanoparticles as multifunctional theranostic platforms for SERS imaging and chemo-photothermal treatment[J]. NANOSCALE,2014,6(23):14514-14522.
APA	Zhang, Weiwei,Wang, Yunqing,Sun, Xiuyan,Wang, Wenhai,&Chen, Lingxin.(2014).Mesoporous titania based yolk-shell nanoparticles as multifunctional theranostic platforms for SERS imaging and chemo-photothermal treatment.NANOSCALE,6(23),14514-14522.
MLA	Zhang, Weiwei,et al."Mesoporous titania based yolk-shell nanoparticles as multifunctional theranostic platforms for SERS imaging and chemo-photothermal treatment".NANOSCALE 6.23(2014):14514-14522.