Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway
	Zhou, Hailong 1,2,3,4; Wu, Huifeng 1; Liao, Chunyang 1; Diao, Xiaoping 2; Zhen, Jiping 2; Chen, Linlin 1; Xue, Qinzhao 1
刊名	TOXICOLOGY MECHANISMS AND METHODS
	2010-07-01
卷号	20 期号:6 页码:279-286
关键词	Persistent organic pollutants AhR pathway toxicology mechanism fish
英文摘要	With the development of industry and agriculture, the cases of cancer and tumor have been increasing gradually in the last 30 years, and quite a few cases are caused by persistent organic pollutants (POPs), some of them belonging to environmental endocrine disruptors, and they have become ubiquitous in the environment, especially in the aquatic ecosystem; so this issue has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) pathway in fish. In order to gain a comprehensive understanding of the AhR pathway, the present paper focuses on reviewing it from four major steps, including formation of cytosolic complex, translocation of AhR, heterodimerization of AhR, and induction of CYP1A. This study summarized the isoform numbers of AhR pathway genes and the expression patterns in the regulation process of POPs toxicology in zebrafish.
收录类别	SCI
语种	英语
WOS记录号	WOS:000280402000001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/32756]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Hainan Univ, Dept Biotechnol, Coll Agr, Haikou 570228, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Hailong,Wu, Huifeng,Liao, Chunyang,et al. Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway[J]. TOXICOLOGY MECHANISMS AND METHODS,2010,20(6):279-286.
APA	Zhou, Hailong.,Wu, Huifeng.,Liao, Chunyang.,Diao, Xiaoping.,Zhen, Jiping.,...&Xue, Qinzhao.(2010).Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway.TOXICOLOGY MECHANISMS AND METHODS,20(6),279-286.
MLA	Zhou, Hailong,et al."Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway".TOXICOLOGY MECHANISMS AND METHODS 20.6(2010):279-286.