Design and Synthesis of Fluorinated Dendrimers for Sensitive F-19 MRI

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Design and Synthesis of Fluorinated Dendrimers for Sensitive F-19 MRI
	Yu, Weijiang 1,2; Yang, Yuqi 3; Bo, Shaowei 4,5; Li, Yu 1,2; Chen, Shizhen 3; Yang, Zhigang 1,2; Zheng, Xing 4,5; Jiang, Zhong-Xing 1,2,4; Zhou, Xin 3
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2015-05-01
卷号	80 期号:9 页码:4443-4449
英文摘要	To achieve high sensitivity for F-19 MRI, a class of novel dendritic molecules with multiple pseudosymmetrical fluorines was designed and efficiently synthesized. Through iterative bromination and Williamson ether synthesis under mild conditions, a fluorinated dendrimer with 540 pseudosymmetrical fluorines was conveniently prepared without performing the group protection in a convergent way. The dendrimer is characterized by a strong F-19 NMR peak and short relaxation times. Eventually, an appreciably enhanced F-19 MRI at an extremely low concentration (18.5 mu M) was achieved, which demonstrated the potential utility of such dendritic molecules in highly sensitive F-19 MRI.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	DETECT PROTEASE ACTIVITY ; MAGNETIC-RESONANCE ; CONTRAST AGENT ; PROBE ; NANOPARTICLES ; CELLS ; WATER
收录类别	SCI
语种	英语
WOS记录号	WOS:000354004600021
公开日期	2015-07-28
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/4742]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Wuhan Univ, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Wuhan 430071, Peoples R China 2.Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Peoples R China 4.Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Educ Dept, Hengyang 421001, Peoples R China 5.Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China
推荐引用方式 GB/T 7714	Yu, Weijiang,Yang, Yuqi,Bo, Shaowei,et al. Design and Synthesis of Fluorinated Dendrimers for Sensitive F-19 MRI[J]. JOURNAL OF ORGANIC CHEMISTRY,2015,80(9):4443-4449.
APA	Yu, Weijiang.,Yang, Yuqi.,Bo, Shaowei.,Li, Yu.,Chen, Shizhen.,...&Zhou, Xin.(2015).Design and Synthesis of Fluorinated Dendrimers for Sensitive F-19 MRI.JOURNAL OF ORGANIC CHEMISTRY,80(9),4443-4449.
MLA	Yu, Weijiang,et al."Design and Synthesis of Fluorinated Dendrimers for Sensitive F-19 MRI".JOURNAL OF ORGANIC CHEMISTRY 80.9(2015):4443-4449.