Study of rare earth encapsulated carbon nanomolecules for biomedical uses

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Study of rare earth encapsulated carbon nanomolecules for biomedical uses
	Qu, L ; Cao, WB ; Xing, GM ; Zhang, J ; Yuan, H ; Tang, J ; Cheng, Y ; Zhang, B ; Zhao, YL ; Lei, H
刊名	JOURNAL OF ALLOYS AND COMPOUNDS
	2006-02-09
卷号	408 页码:400-404
关键词	Gd-metallofullerenol Gd@C-82(OH)(22) stability MRI contrast agent in vivo
英文摘要	Gd@C-82(OH)(40) has been proposed to be as a new generation of the magnetic resonance imaging (MRI) contrast agent, but water-soluble fullerenols Gd@C-82(OH)(n) with n > 36 can easily lead to open-caged structures of a high instability. This restricts the practical bio-uses of Gd-metallofullerenols with a large number of hydroxyl groups. To explore how the imaging efficiency varies with decreasing hydroxyl number in Gd@C-82(OH)(22) of a good stability in vivo, Gd@C-82(OH)(22) was prepared, characterized and its imaging efficiency in mice was studied. This work aims at searching a chemical form of water-soluble Gd-metallofullerenols that satisfy both requirements of the good stability and high imaging efficiency in vivo. The results indicate that the proton relaxivity of Gd@C-82(OH)(22) is lower than that of Gd@C-82(OH)(40), but still higher than the commercial Gd-DTPA MRI contrast agent. (c) 2005 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Physical ; Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
研究领域[WOS]	Chemistry ; Materials Science ; Metallurgy & Metallurgical Engineering
关键词[WOS]	METALLOFULLERENES
收录类别	ISTP ; SCI
语种	英语
WOS记录号	WOS:000235445300097
公开日期	2015-07-28
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/4608]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100039, Peoples R China 2.Chinese Acad Sci, Inst Phys & Math, State Key Lab Nucl Magnet Resonance & Atom & Mol, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Qu, L,Cao, WB,Xing, GM,et al. Study of rare earth encapsulated carbon nanomolecules for biomedical uses[J]. JOURNAL OF ALLOYS AND COMPOUNDS,2006,408:400-404.
APA	Qu, L.,Cao, WB.,Xing, GM.,Zhang, J.,Yuan, H.,...&Lei, H.(2006).Study of rare earth encapsulated carbon nanomolecules for biomedical uses.JOURNAL OF ALLOYS AND COMPOUNDS,408,400-404.
MLA	Qu, L,et al."Study of rare earth encapsulated carbon nanomolecules for biomedical uses".JOURNAL OF ALLOYS AND COMPOUNDS 408(2006):400-404.