Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence
	Wang, Xuxia ; Qian, Junchao ; He, Rui ; Wei, Li ; Liu, Nianqing ; Zhang, Zhiyong ; Huang, Yuying ; Lei, Hao
刊名	MAGNETIC RESONANCE IN MEDICINE
	2006-09-01
卷号	56 期号:3 页码:474-480
关键词	magnetic resonance synchrotron radiation X-ray fluorescence brain transient focal ischemia rat
英文摘要	Previous studies have found that rats subjected to 15-min transient middle cerebral artery occlusion (MCAO) show neurodegeneration in the dorsolateral striatum only, and the resulting striatal lesion is associated with increased T-1-weighted (T1W) signal intensity (SI) and decreased T-2-weighted (T2W SI at 2-8 weeks after the initial ischemia. It has been shown that the delayed increase in T1W SI in the ischemic region is associated with deposition of paramagnetic manganese ions. However, it has been suggested that other mechanisms, such as tissue calcification and lipid accumulation, also contribute to the relaxation time changes. To clarify this issue, we measured changes in relaxation times, lipid accumulation, and elemental distributions in the brain of rats subjected to 15-min MCAO using MRI, in vivo H-1 MR spectroscopy (MRS), and synchrotron radiation X-ray fluorescence (SRXRF). The results show that a delayed (2 weeks after ischemia) increase in T1W SI in the ischemic striatum is associated with significant increases in manganese, calcium, and iron, but without evident accumulation of MRS-visible lipids or hydroxyapatite precipitation. It was also found that 15-min MCAO results in acutely reduced N-acetylaspartate (NAA)/creatine (Cr) ratio in the ipsilateral striatum, which recovers to the control level at 2 weeks after ischemia.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]	Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]	CEREBRAL-ARTERY OCCLUSION ; FOREBRAIN ISCHEMIA ; CORTICAL NEUROGENESIS ; CALCIUM ACCUMULATION ; EXPERIMENTAL STROKE ; IRON DEPOSITION ; ADULT RATS ; BRAIN ; SPECTROSCOPY ; MRI
收录类别	SCI
语种	英语
WOS记录号	WOS:000240245600002
公开日期	2015-07-28
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/4589]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China 3.Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Analyt Techn, Beijing 100080, Peoples R China 4.Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Lab, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xuxia,Qian, Junchao,He, Rui,et al. Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence[J]. MAGNETIC RESONANCE IN MEDICINE,2006,56(3):474-480.
APA	Wang, Xuxia.,Qian, Junchao.,He, Rui.,Wei, Li.,Liu, Nianqing.,...&Lei, Hao.(2006).Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence.MAGNETIC RESONANCE IN MEDICINE,56(3),474-480.
MLA	Wang, Xuxia,et al."Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence".MAGNETIC RESONANCE IN MEDICINE 56.3(2006):474-480.