ECR-MAPK Regulation in Liver Early Development

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	ECR-MAPK Regulation in Liver Early Development
	Zhao, Xiu-Ju 1,2; Zhuo, Hexian 3
刊名	BIOMED RESEARCH INTERNATIONAL
	2014
英文摘要	Early growth is connected to a key link between embryonic development and aging. In this paper, liver gene expression profiles were assayed at postnatal day 22 and week 16 of age. Meanwhile another independent animal experiment and cell culture were carried out for validation. Significance analysis of microarrays, qPCR verification, drug induction/inhibition assays, and metabonomics indicated that alpha-2u globulin (extracellular region)-socs2 (-SH2-containing signals/receptor tyrosine kinases)-ppp2r2a/pik3c3 (MAPK signaling)-hsd3b5/cav2 (metabolism/organization) plays a vital role in early development. Taken together, early development of male rats is ECR and MAPK-mediated coordination of cancer-like growth and negative regulations. Our data represent the first comprehensive description of early individual development, which could be a valuable basis for understanding the functioning of the gene interaction network of infant development.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]	HEPATIC GENE-EXPRESSION ; MICROARRAY DATA ; SPECTROSCOPY ; ACTIVATION ; RECEPTOR ; CXCL13 ; CANCER ; MODEL ; DIET
收录类别	SCI
语种	英语
WOS记录号	WOS:000347793700001
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1536]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Collaborat Innovat Ctr Proc Agr Prod Hubei Prov, Wuhan 430023, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 3.Xinxiang Inst Drug Control, Xinxiang 453000, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Xiu-Ju,Zhuo, Hexian. ECR-MAPK Regulation in Liver Early Development[J]. BIOMED RESEARCH INTERNATIONAL,2014.
APA	Zhao, Xiu-Ju,&Zhuo, Hexian.(2014).ECR-MAPK Regulation in Liver Early Development.BIOMED RESEARCH INTERNATIONAL.
MLA	Zhao, Xiu-Ju,et al."ECR-MAPK Regulation in Liver Early Development".BIOMED RESEARCH INTERNATIONAL (2014).