Systemic Responses of BALB/c Mice to Salmonella typhimurium Infection

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Systemic Responses of BALB/c Mice to Salmonella typhimurium Infection
	Zhu, Xiaoyang 1,5; Lei, Hehua 1; Wu, Junfang 1; Li, Jia V.3; Tang, Huiru 1,2; Wang, Yulan 1,4
刊名	JOURNAL OF PROTEOME RESEARCH
	2014-10-01
卷号	13 期号:10 页码:4436-4445
关键词	infectious disease itaconic acid metabonomics NMR Salmonella typhimurium
英文摘要	Salmonella typhimurium is a bacterial pathogen that poses a great threat to humans and animals. In order to discover hosts responses to S. typhimurium infection, we collected and analyzed biofluids and organ tissues from mice which had ingested S. typhimurium. We employed H-1 NMR spectroscopy coupled with multivariate data analysis and immunological techniques. The results indicate that infection leads to a severe impact on mice spleen and ileum, which are characterized by splenomegaly and edematous villi, respectively. We found that increased levels of itaconic acid were correlated with the presence of splenomegaly during infection and may play an important role in Salmonella-containing vacuole acidification. In addition, metabonomic analyses of urine displayed the development of salmonellosis in mice, which is characterized by dynamic changes in energy metabolism. Furthermore, we found that the presence of S. typhimurium activated an anti-oxidative response in infected mice. We also observed changes in the gut microbial co-metabolites (hippurate, TMAO, TMA, methylamine). This investigation sheds much needed light on the hostpathogen interactions of S. typhimurium, providing further information to deepen our understanding of the long co-evolution process between hosts and infective bacteria.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemical Research Methods
研究领域[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	TAURINE TRANSPORTER EXPRESSION ; CORNEAL EPITHELIAL-CELLS ; NITRIC-OXIDE SYNTHESIS ; III SECRETION SYSTEM ; ISOCITRATE LYASE ; SEROVAR TYPHIMURIUM ; ITACONIC ACID ; MOUSE MODEL ; MYCOBACTERIUM-TUBERCULOSIS ; CONTAINING VACUOLE
收录类别	SCI
语种	英语
WOS记录号	WOS:000342719200019
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1392]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance,Key Lab Magnet Resonan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn Biospect & Metabol, Shanghai 200433, Peoples R China 3.Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Surg & Canc, London SW7 2AZ, England 4.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Xiaoyang,Lei, Hehua,Wu, Junfang,et al. Systemic Responses of BALB/c Mice to Salmonella typhimurium Infection[J]. JOURNAL OF PROTEOME RESEARCH,2014,13(10):4436-4445.
APA	Zhu, Xiaoyang,Lei, Hehua,Wu, Junfang,Li, Jia V.,Tang, Huiru,&Wang, Yulan.(2014).Systemic Responses of BALB/c Mice to Salmonella typhimurium Infection.JOURNAL OF PROTEOME RESEARCH,13(10),4436-4445.
MLA	Zhu, Xiaoyang,et al."Systemic Responses of BALB/c Mice to Salmonella typhimurium Infection".JOURNAL OF PROTEOME RESEARCH 13.10(2014):4436-4445.